Exercise testing for non-invasive assessment of atrial electrophysiology in patients with persistent atrial fibrillation

O. Husser, D. Husser, M. Stridh, L. Sörnmo, H. U. Klein, Andreas Bollmann

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

Abstract

The abstract with its heading should not be more than 75 mm long. This is equivalent to 18 lines of text. Leave 1 line space at the bottom of the abstract before continuing with the next heading. The autonomic nervous system modulates atrial electrophysiology in atrial fibrillation (AF). The purpose of this study was (1) to non-invasively characterize the effects of exercise on atrial fibrillatory rate as marker of atrial refractoriness in patients with persistent AF and (2) to identify clinical and electrocardiographic predictors for rate response. In 15 patients with persistent AF, mean fibrillatory rate assessed by spatiotemporal QRST cancellation and time-frequency analysis remained unchanged with exercise. There were, however, 6 responders (rate change > 2.5%), with either a rate increase (N=5, 25±9 fpm) or decrease (N=1, -13 fpm). Absolute fibrillatory rate change (%) correlated inversely with baseline fibrillatory rate (r= -0.543, p=.045). In conclusion, sympathetic activation by exercise modulates atrial electrophysiology in some patients which can be monitored using time-frequency analysis. Higher baseline fibrillatory rates are associated with less autonomic modulation indicating advanced electrical remodeling.

Original languageEnglish
Title of host publication2006 Computers in Cardiology, CIC
Pages21-24
Number of pages4
Volume33
Publication statusPublished - 2006 Dec 1
Event2006 Computers in Cardiology, CIC - Valencia, Spain
Duration: 2006 Sep 172006 Sep 20

Conference

Conference2006 Computers in Cardiology, CIC
Country/TerritorySpain
CityValencia
Period2006/09/172006/09/20

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems

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