Abstract
The induction of host signal transduction cascades by bacterial pathogens contributes directly to their virulence. In addition to the pore-forming cytolysin pneumolysin, several surface-exposed proteins of Streptococcus pneumoniae are also potent modulators of complex host signaling pathways. These pneumococcal surface proteins either directly mediate adhesion of pneumococci to specific cell surface receptors or recruit extracellular matrix or serum components as molecular bridges for binding to cellular receptors. In turn, adhesion triggers and subverts host signal transduction cascades to promote pneumococcal translocation across tissue barriers and dissemination within host tissues. This chapter summarizes the current knowledge of how pneumolysin and major adhesins manipulate host signaling pathways. The chapter will provide a structured overview of the signaling profiles induced by pneumococci, focusing on the receptors required and comparing the key signaling molecules and intracellular responses involved.
Original language | English |
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Title of host publication | Streptococcus Pneumoniae |
Subtitle of host publication | Molecular Mechanisms of Host-Pathogen Interactions |
Publisher | Elsevier |
Pages | 347-362 |
Number of pages | 16 |
ISBN (Electronic) | 9780124114531 |
ISBN (Print) | 9780124105300 |
DOIs | |
Publication status | Published - 2015 May 11 |
Subject classification (UKÄ)
- Medicinal Chemistry
Free keywords
- Adhesion
- Extracellular matrix
- Integrin
- Pneumolysin
- Signal transduction
- Streptococcus pneumoniae
- Surface protein