Abstract
Arsenic is an established carcinogen and a risk factor for several non-malignant diseases. Mechanisms of arsenic toxicity may include interference with gene expression. The impact of arsenic exposure on gene expression was evaluated in women (n = 80) living in the Puna of the northern Argentinian Andes with varying concentrations (10–1251 μg/L) of arsenic in drinking water. DirectHyb HumanHT-12 v4.0 was used for genome wide gene expression analysis. Robust linear regression model was used to each array to evaluate the relations between arsenic exposure, gene expression and with the influence of arsenic metabolism efficiency. Also, Ingenuity Pathway Analysis (IPA) was performed to look for relevant pathways, diseases, networks etc. associated with the genes. In the association between arsenic and gene expression, most of the genes were downregu-lated. Pathway analyses revealed different expression pattern associated with arsenic exposure between women with high and low urinary %MMA, indicating variation in arsenic susceptibility by arsenic-methylation.
Original language | English |
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Title of host publication | Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016 |
Publisher | CRC Press/Balkema |
Pages | 448-449 |
Number of pages | 2 |
ISBN (Print) | 9781138029415 |
Publication status | Published - 2016 |
Event | 6th International Congress on Arsenic in the Environment, AS 2016 - Stockholm, Sweden Duration: 2016 Jun 19 → 2016 Jun 23 |
Conference
Conference | 6th International Congress on Arsenic in the Environment, AS 2016 |
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Country/Territory | Sweden |
City | Stockholm |
Period | 2016/06/19 → 2016/06/23 |
Subject classification (UKÄ)
- Environmental Health and Occupational Health