Exposure to Polybrominated Diphenyl Ethers and Male Reproductive Function in Greenland, Poland and Ukraine.

Gunnar Toft, Virissa Lenters, Roel Vermeulen, Dick Heederik, Cathrine Thomsen, Georg Becher, Aleksander Giwercman, Davide Bizzaro, Gian Carlo Manicardi, Marcello Spanò, Lars Rylander, Henning S Pedersen, Paweł Struciński, Valentyna Zviezdai, Jens Peter Bonde

Research output: Contribution to journalArticlepeer-review

14 Citations (SciVal)

Abstract

Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.
Original languageEnglish
Pages (from-to)1-7
JournalReproductive Toxicology
Volume43
DOIs
Publication statusPublished - 2014

Subject classification (UKÄ)

  • Obstetrics, Gynecology and Reproductive Medicine

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