Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1 and 3 in Gastric and Esophageal Adenocarcinoma.

Charlotta Hedner; David Borg; Björn Nodin; Emelie Karnevi; Karin Jirström; Jakob Eberhard

doi:10.1371/journal.pone.0148101

Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1 and 3 in Gastric and Esophageal Adenocarcinoma.

Charlotta Hedner, David Borg, Björn Nodin, Emelie Karnevi, Karin Jirström, Jakob Eberhard

Research output: Contribution to journal › Article › peer-review

Abstract

Gastric and esophageal adenocarcinomas are major global cancer burdens. These cancer forms are characterized by a poor prognosis and a modest response to chemo- radio- and targeted treatment. Hence there is an obvious need for further enhanced diagnostic and treatment strategies. The aim of this study was to examine the expression and prognostic impact of human epidermal growth factor receptor 1 (HER1/EGFR) and 3 (HER3), as well as the occurrence of EGFR and KRAS mutations in gastric and esophageal adenocarcinoma.

Original language	English
Article number	e0148101
Journal	PLoS ONE
Volume	11
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0148101
Publication status	Published - 2016

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0148101

http://www.ncbi.nlm.nih.gov/pubmed/26844548?dopt=Abstract

1 Doctoral Thesis (compilation)

Prognostic biomarkers in upper gastrointestinal adenocarcinoma
HEDNER, CHARLOTTA., 2016, Lund: Lund University: Faculty of Medicine. 78 p.
Research output: Thesis › Doctoral Thesis (compilation)

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title = "Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1 and 3 in Gastric and Esophageal Adenocarcinoma.",

abstract = "Gastric and esophageal adenocarcinomas are major global cancer burdens. These cancer forms are characterized by a poor prognosis and a modest response to chemo- radio- and targeted treatment. Hence there is an obvious need for further enhanced diagnostic and treatment strategies. The aim of this study was to examine the expression and prognostic impact of human epidermal growth factor receptor 1 (HER1/EGFR) and 3 (HER3), as well as the occurrence of EGFR and KRAS mutations in gastric and esophageal adenocarcinoma.",

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AU - Karnevi, Emelie

AU - Jirström, Karin

AU - Eberhard, Jakob

PY - 2016

Y1 - 2016

N2 - Gastric and esophageal adenocarcinomas are major global cancer burdens. These cancer forms are characterized by a poor prognosis and a modest response to chemo- radio- and targeted treatment. Hence there is an obvious need for further enhanced diagnostic and treatment strategies. The aim of this study was to examine the expression and prognostic impact of human epidermal growth factor receptor 1 (HER1/EGFR) and 3 (HER3), as well as the occurrence of EGFR and KRAS mutations in gastric and esophageal adenocarcinoma.

AB - Gastric and esophageal adenocarcinomas are major global cancer burdens. These cancer forms are characterized by a poor prognosis and a modest response to chemo- radio- and targeted treatment. Hence there is an obvious need for further enhanced diagnostic and treatment strategies. The aim of this study was to examine the expression and prognostic impact of human epidermal growth factor receptor 1 (HER1/EGFR) and 3 (HER3), as well as the occurrence of EGFR and KRAS mutations in gastric and esophageal adenocarcinoma.

U2 - 10.1371/journal.pone.0148101

DO - 10.1371/journal.pone.0148101

M3 - Article

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SN - 1932-6203

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JO - PLoS ONE

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ER -

Expression and Prognostic Significance of Human Epidermal Growth Factor Receptors 1 and 3 in Gastric and Esophageal Adenocarcinoma.

Abstract

Subject classification (UKÄ)

UN SDGs

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Research output

Prognostic biomarkers in upper gastrointestinal adenocarcinoma

Cite this