Expression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events.

Annelie Shami; Christoffer Tengryd; Giuseppe Asciutto; Eva Bengtsson; Jan Nilsson; Anna Hultgårdh; Isabel Goncalves

doi:10.1016/j.atherosclerosis.2015.06.023

Expression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events.

Annelie Shami, Christoffer Tengryd, Giuseppe Asciutto, Eva Bengtsson, Jan Nilsson, Anna Hultgårdh, Isabel Goncalves

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Abstract

The small leucine-rich proteoglycans fibromodulin and lumican are functionally related extracellular matrix proteins involved in the regulation of collagen fiber formation. Fibromodulin-deficient apolipoprotein E-null mice have decreased vascular retention of lipids and reduced development of atherosclerosis suggesting that fibromodulin may influence the disease process. The aim of the present study was to investigate if fibromodulin and lumican are expressed in human carotid plaques and to determine if their expression is associated with the occurrence of preoperative symptoms and with risk for postoperative cardiovascular events.

Original language	English
Pages (from-to)	701-708
Journal	Atherosclerosis
Volume	241
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2015.06.023
Publication status	Published - 2015

Subject classification (UKÄ)

Cardiology and Cardiovascular Disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.atherosclerosis.2015.06.023

shami_et_al

http://www.ncbi.nlm.nih.gov/pubmed/26125412?dopt=Abstract

1 Doctoral Thesis (compilation)

Extracellular matrix in atherosclerotic plaques: its role in plaque stability
Tengryd, C., 2020, Lund: Lund University, Faculty of Medicine. 102 p.
Research output: Thesis › Doctoral Thesis (compilation)

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title = "Expression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events.",

abstract = "The small leucine-rich proteoglycans fibromodulin and lumican are functionally related extracellular matrix proteins involved in the regulation of collagen fiber formation. Fibromodulin-deficient apolipoprotein E-null mice have decreased vascular retention of lipids and reduced development of atherosclerosis suggesting that fibromodulin may influence the disease process. The aim of the present study was to investigate if fibromodulin and lumican are expressed in human carotid plaques and to determine if their expression is associated with the occurrence of preoperative symptoms and with risk for postoperative cardiovascular events.",

author = "Annelie Shami and Christoffer Tengryd and Giuseppe Asciutto and Eva Bengtsson and Jan Nilsson and Anna Hultg{\aa}rdh and Isabel Goncalves",

year = "2015",

doi = "10.1016/j.atherosclerosis.2015.06.023",

language = "English",

volume = "241",

pages = "701--708",

journal = "Atherosclerosis",

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T1 - Expression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events.

AU - Shami, Annelie

AU - Tengryd, Christoffer

AU - Asciutto, Giuseppe

AU - Bengtsson, Eva

AU - Nilsson, Jan

AU - Hultgårdh, Anna

AU - Goncalves, Isabel

PY - 2015

Y1 - 2015

N2 - The small leucine-rich proteoglycans fibromodulin and lumican are functionally related extracellular matrix proteins involved in the regulation of collagen fiber formation. Fibromodulin-deficient apolipoprotein E-null mice have decreased vascular retention of lipids and reduced development of atherosclerosis suggesting that fibromodulin may influence the disease process. The aim of the present study was to investigate if fibromodulin and lumican are expressed in human carotid plaques and to determine if their expression is associated with the occurrence of preoperative symptoms and with risk for postoperative cardiovascular events.

AB - The small leucine-rich proteoglycans fibromodulin and lumican are functionally related extracellular matrix proteins involved in the regulation of collagen fiber formation. Fibromodulin-deficient apolipoprotein E-null mice have decreased vascular retention of lipids and reduced development of atherosclerosis suggesting that fibromodulin may influence the disease process. The aim of the present study was to investigate if fibromodulin and lumican are expressed in human carotid plaques and to determine if their expression is associated with the occurrence of preoperative symptoms and with risk for postoperative cardiovascular events.

U2 - 10.1016/j.atherosclerosis.2015.06.023

DO - 10.1016/j.atherosclerosis.2015.06.023

M3 - Article

C2 - 26125412

SN - 1879-1484

VL - 241

SP - 701

EP - 708

JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

Expression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events.

Abstract

Subject classification (UKÄ)

UN SDGs

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Research output

Extracellular matrix in atherosclerotic plaques: its role in plaque stability

Cite this