Expression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events.

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Abstract

The small leucine-rich proteoglycans fibromodulin and lumican are functionally related extracellular matrix proteins involved in the regulation of collagen fiber formation. Fibromodulin-deficient apolipoprotein E-null mice have decreased vascular retention of lipids and reduced development of atherosclerosis suggesting that fibromodulin may influence the disease process. The aim of the present study was to investigate if fibromodulin and lumican are expressed in human carotid plaques and to determine if their expression is associated with the occurrence of preoperative symptoms and with risk for postoperative cardiovascular events.
Original languageEnglish
Pages (from-to)701-708
JournalAtherosclerosis
Volume241
Issue number2
DOIs
Publication statusPublished - 2015

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems

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