Expression of microRNA-1234 related signal transducer and activator of transcription 3 in patients with diffuse large B-cell lymphoma of activated B-cell like type from high and low infectious disease areas

Therese Högfeldt, Per Johnsson, Dan Grandér, Abeer A. Bahnassy, Anna Porwit, Salem Eid, Anders Österborg, Abdel Rahman N. Zekri, Joachim Lundahl, Mustafa Hussein Khaled, Håkan Mellstedt, Ali Moshfegh

Research output: Contribution to journalArticlepeer-review

Abstract

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, and infectious agents are suspected to be involved in the tumorigenesis of DLBCL. MicroRNAs (miRNAs) are non-coding RNAs modulating protein expression. We compared miRNA expression profiles in lymph node tissues of patients with DLBCL of the activated B-cell like (ABC) type from two geographical areas with different background exposures, Sweden and Egypt. We showed previously that DLBCL tissues of the ABC-type in Swedish patients had a higher expression of signal transducer and activator of transcription 3 (STAT3) compared to Egyptian patients. Here, we analyzed the involvement of miRNAs in STAT3 regulation. miR-1234 was significantly up-regulated in Egyptian patients with DLBCL compared to Swedish patients (p < 0.03). The miR-1234 expression level correlated inversely with the expression of STAT3. The Stat3 protein was down-regulated in cells transfected with miR-1234, suggesting that STAT3 might be a potential target for miR-1234. miR-1234 and STAT3 might be involved in the tumorigenesis of DLBCL of ABC type and possibly associated with environmental background exposure.

Original languageEnglish
Pages (from-to)1158-1165
JournalLeukemia and Lymphoma
Volume55
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Free keywords

  • DLBCL
  • MiRNA
  • STAT3

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