Expression of VEGF and VEGF Receptors in Childhood Precursor B-cell Acute Lymphoblastic Leukemia Evaluated by Immunohistochemistry.

Eva Diffner, Fredrika Gauffin, Lola Anagnostaki, Ann Nordgren, Bertil Gustafsson, Birgitta Sander, Britt Gustafsson, Jenny L Persson

Research output: Contribution to journalArticlepeer-review

9 Citations (SciVal)

Abstract

Perturbation in the expression and signaling pathways of vascular endothelial growth factor (VEGF) has been linked to pathogenesis of hematologic malignancies. We investigated the expression and clinical importance of VEGF and two of its receptors, VEGFR-1 and VEGFR-2, in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL) by using immunohistochemistry. These angiogenic proteins were expressed in the majority of leukemic bone marrow samples. Notably, pre-B ALL patients had significantly increased expression of VEGFR-1 compared with no expression in the nonmalignant group, indicating a link between VEGFR-1 protein expression and pre-B ALL. These novel findings suggest that VEGFR-1 may have clinical importance in childhood pre-B ALL.
Original languageEnglish
Pages (from-to)696-701
JournalJournal of Pediatric Hematology/Oncology
Volume31
DOIs
Publication statusPublished - 2009

Subject classification (UKÄ)

  • Pediatrics

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