External Validation of the DAPT Score in a Nationwide Population

Peter Ueda, Tomas Jernberg, Stefan James, Joakim Alfredsson, David Erlinge, Elmir Omerovic, Jonas Persson, Annica Ravn-Fischer, Per Tornvall, Bodil Svennblad, Christoph Varenhorst

Research output: Contribution to journalArticlepeer-review

42 Citations (SciVal)

Abstract

Background: The dual antiplatelet therapy (DAPT) score guides decisions on DAPT duration after coronary stenting by simultaneously predicting ischemic and bleeding risk. Objectives: This study sought to assess the performance of the DAPT score in a nationwide real-world population. Methods: The study used register data in Sweden (2006 to 2014) and followed 41,101 patients who had undergone 12 months of event-free DAPT, from months 12 to 30 after stenting. Risk of myocardial infarction (MI) or stent thrombosis, major adverse cardiovascular and cerebrovascular events (MACCE) (MI, stroke, and all-cause death), and fatal or major bleeding were compared according to DAPT score. Results: The score had a discrimination of 0.58 (95% confidence interval [CI]: 0.56 to 0.60) for MI or stent thrombosis, 0.54 (95% CI: 0.53 to 0.55) for MACCE, and 0.49 (95% CI: 0.45 to 0.53) for fatal or major bleeding. Risk of MI or stent thrombosis was significantly increased at scores of ≥3 while MACCE risk followed a J-shaped pattern and increased at scores of ≥4. Absolute differences in fatal or major bleeding risk were small between scores. Event rates of ischemic and bleeding outcomes in patients with high (≥2) and low (<2) scores differed compared to the DAPT Study from which the score was derived; fatal or major bleeding rates were approximately one-half of those in the placebo arm of the DAPT Study. Conclusions: In a nationwide population, the DAPT score did not adequately discriminate ischemic and bleeding risk, the relationship between score and ischemic risk did not correspond to the suggested decision rule for extended DAPT, and risk of bleeding was lower compared with the DAPT Study. The score and its decision rule may not be generalizable to real-world populations.

Original languageEnglish
Pages (from-to)1069-1078
Number of pages10
JournalJournal of the American College of Cardiology
Volume72
Issue number10
DOIs
Publication statusPublished - 2018 Sep 4

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems

Keywords

  • bleeding
  • dual antiplatelet therapy
  • myocardial infarction
  • risk prediction
  • risk score

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