Extracellular Matrix Biomarker, Fibulin-1, Is Closely Related to NT-proBNP and Soluble Urokinase Plasminogen Activator Receptor in Patients with Aortic Valve Stenosis (The SEAS Study).

Ruan Kruger; Lars M Rasmussen; William S Argraves; Jesper Eugen-Olsen; Olav W Nielsen; Adam Blyme; Ronnie Willenheimer; Kristian Wachtell; Michael H Olsen

doi:10.1371/journal.pone.0101522

Extracellular Matrix Biomarker, Fibulin-1, Is Closely Related to NT-proBNP and Soluble Urokinase Plasminogen Activator Receptor in Patients with Aortic Valve Stenosis (The SEAS Study).

Ruan Kruger, Lars M Rasmussen, William S Argraves, Jesper Eugen-Olsen, Olav W Nielsen, Adam Blyme, Ronnie Willenheimer, Kristian Wachtell, Michael H Olsen

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Abstract

Fibulin-1, a circulating extracellular matrix glycoprotein, has been associated with arterial disease and elevated N-terminal prohormone B-type natriuretic peptide (NT-proBNP) in diabetes. Soluble urokinase plasminogen activator receptor (suPAR), a marker of inflammation, has been associated with subclinical atherosclerosis. Therefore, we aimed to explore the interplay between these biomarkers and mild to moderate aortic valve stenosis (AS).

Original language	English
Article number	e101522
Journal	PLoS ONE
Volume	9
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0101522
Publication status	Published - 2014

Subject classification (UKÄ)

Cardiac and Cardiovascular Systems

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Plos_Kruger_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25014213?dopt=Abstract

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Kruger, R., Rasmussen, L. M., Argraves, W. S., Eugen-Olsen, J., Nielsen, O. W., Blyme, A., Willenheimer, R., Wachtell, K., & Olsen, M. H. (2014). Extracellular Matrix Biomarker, Fibulin-1, Is Closely Related to NT-proBNP and Soluble Urokinase Plasminogen Activator Receptor in Patients with Aortic Valve Stenosis (The SEAS Study). PLoS ONE, 9(7), Article e101522. https://doi.org/10.1371/journal.pone.0101522

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title = "Extracellular Matrix Biomarker, Fibulin-1, Is Closely Related to NT-proBNP and Soluble Urokinase Plasminogen Activator Receptor in Patients with Aortic Valve Stenosis (The SEAS Study).",

abstract = "Fibulin-1, a circulating extracellular matrix glycoprotein, has been associated with arterial disease and elevated N-terminal prohormone B-type natriuretic peptide (NT-proBNP) in diabetes. Soluble urokinase plasminogen activator receptor (suPAR), a marker of inflammation, has been associated with subclinical atherosclerosis. Therefore, we aimed to explore the interplay between these biomarkers and mild to moderate aortic valve stenosis (AS).",

author = "Ruan Kruger and Rasmussen, {Lars M} and Argraves, {William S} and Jesper Eugen-Olsen and Nielsen, {Olav W} and Adam Blyme and Ronnie Willenheimer and Kristian Wachtell and Olsen, {Michael H}",

year = "2014",

doi = "10.1371/journal.pone.0101522",

language = "English",

volume = "9",

journal = "PLoS ONE",

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Kruger, R, Rasmussen, LM, Argraves, WS, Eugen-Olsen, J, Nielsen, OW, Blyme, A, Willenheimer, R, Wachtell, K & Olsen, MH 2014, 'Extracellular Matrix Biomarker, Fibulin-1, Is Closely Related to NT-proBNP and Soluble Urokinase Plasminogen Activator Receptor in Patients with Aortic Valve Stenosis (The SEAS Study).', PLoS ONE, vol. 9, no. 7, e101522. https://doi.org/10.1371/journal.pone.0101522

TY - JOUR

T1 - Extracellular Matrix Biomarker, Fibulin-1, Is Closely Related to NT-proBNP and Soluble Urokinase Plasminogen Activator Receptor in Patients with Aortic Valve Stenosis (The SEAS Study).

AU - Kruger, Ruan

AU - Rasmussen, Lars M

AU - Argraves, William S

AU - Eugen-Olsen, Jesper

AU - Nielsen, Olav W

AU - Blyme, Adam

AU - Willenheimer, Ronnie

AU - Wachtell, Kristian

AU - Olsen, Michael H

PY - 2014

Y1 - 2014

N2 - Fibulin-1, a circulating extracellular matrix glycoprotein, has been associated with arterial disease and elevated N-terminal prohormone B-type natriuretic peptide (NT-proBNP) in diabetes. Soluble urokinase plasminogen activator receptor (suPAR), a marker of inflammation, has been associated with subclinical atherosclerosis. Therefore, we aimed to explore the interplay between these biomarkers and mild to moderate aortic valve stenosis (AS).

AB - Fibulin-1, a circulating extracellular matrix glycoprotein, has been associated with arterial disease and elevated N-terminal prohormone B-type natriuretic peptide (NT-proBNP) in diabetes. Soluble urokinase plasminogen activator receptor (suPAR), a marker of inflammation, has been associated with subclinical atherosclerosis. Therefore, we aimed to explore the interplay between these biomarkers and mild to moderate aortic valve stenosis (AS).

U2 - 10.1371/journal.pone.0101522

DO - 10.1371/journal.pone.0101522

M3 - Article

C2 - 25014213

SN - 1932-6203

VL - 9

JO - PLoS ONE

JF - PLoS ONE

IS - 7

M1 - e101522

ER -

Extracellular Matrix Biomarker, Fibulin-1, Is Closely Related to NT-proBNP and Soluble Urokinase Plasminogen Activator Receptor in Patients with Aortic Valve Stenosis (The SEAS Study).

Abstract

Subject classification (UKÄ)

UN SDGs

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