Acute cellular rejection (ACR) is a leading cause of graft loss and death after heart transplantation despite effective immunosuppressive therapies. The identification of factors that impair graft vascular barrier function or promote immune cell recruitment during ACR could provide new therapeutic opportunities for the treatment of patients who receive transplants. In 2 ACR cohorts, we found the extracellular vesicle-associated cytokine TWEAK to be elevated during ACR. Vesicular TWEAK promoted expression of proinflammatory genes and the release of chemoattractant cytokines from human cardiac endothelial cells. We conclude that vesicular TWEAK is a novel target with potential therapeutic implications in ACR.

Original languageEnglish
Pages (from-to)439-456
Number of pages18
JournalJACC: Basic to Translational Science
Issue number5
Publication statusPublished - 2023 May

Subject classification (UKÄ)

  • Surgery

Free keywords

  • acute cellular rejection
  • chronic rejection
  • extracellular vesicle


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