F-18-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study

Karen Juul Mylam; Lale Kostakoglu; Martin Hutchings; Morton Coleman; Dominick Lamonica; Myron S. Czuczman; Louis F. Diehl; Anne L. Nielsen; Paw Jensen; Annika Loft; Helle W. Hendel; Victor Iyer; Sirpa Leppa; Sirkku Jyrkkio; Harald Holte; Mikael Eriksson; Dorte Gillstrom; Per B. Hansen; Marko Seppanen; Karin Hjorthaug; Peter de Nully Brown; Lars M. Pedersen

doi:10.3109/10428194.2014.975800

F-18-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study

Karen Juul Mylam, Lale Kostakoglu, Martin Hutchings, Morton Coleman, Dominick Lamonica, Myron S. Czuczman, Louis F. Diehl, Anne L. Nielsen, Paw Jensen, Annika Loft, Helle W. Hendel, Victor Iyer, Sirpa Leppa, Sirkku Jyrkkio, Harald Holte, Mikael Eriksson, Dorte Gillstrom, Per B. Hansen, Marko Seppanen, Karin HjorthaugPeter de Nully Brown, Lars M. Pedersen

Tumor microenvironment

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated the predictive value of interim positon emission tomography (I-PET) after one course of chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients with DLBCL were enrolled. All patients had PET/computed tomography (CT) scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to International Harmonization Project criteria (IHP), Deauville 5-point scale (D 5PS) with scores 1-3 considered negative (D 5PS>3) and D 5PS with scores 1-4 considered negative (D 5PS = 5). Ratios of tumor maximum standardized uptake value (SUVmax) to liver SUVmax were also analyzed. We found no difference in progression-free survival (PFS) between PET-negative and PET-positive patients according to IHP and D 5PS>3. The 2-year PFS using D 5PS = 5 was 50.9% in the PET-positive group and 84.8% in the PET-negative group (p = 0.002). A tumor/liver SUVmax cut-off of 3.1 to distinguish D 5PS scores of 4 and 5 provided the best prognostic value. PET after one course of chemotherapy was not able to safely discriminate PET-positive and PET-negative patients in different prognostic groups.

Original language	English
Pages (from-to)	2005-2012
Journal	Leukemia & Lymphoma
Volume	56
Issue number	7
DOIs	https://doi.org/10.3109/10428194.2014.975800
Publication status	Published - 2015

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

Deauville 5-point scale
diffuse large B-cell lymphoma
predictive value
Interim PET/CT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/10428194.2014.975800

Cite this

Mylam, K. J., Kostakoglu, L., Hutchings, M., Coleman, M., Lamonica, D., Czuczman, M. S., Diehl, L. F., Nielsen, A. L., Jensen, P., Loft, A., Hendel, H. W., Iyer, V., Leppa, S., Jyrkkio, S., Holte, H., Eriksson, M., Gillstrom, D., Hansen, P. B., Seppanen, M., ... Pedersen, L. M. (2015). F-18-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study. Leukemia & Lymphoma, 56(7), 2005-2012. https://doi.org/10.3109/10428194.2014.975800

@article{365ae29b805d4e2f882a934a93944df1,

title = "F-18-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study",

abstract = "We evaluated the predictive value of interim positon emission tomography (I-PET) after one course of chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients with DLBCL were enrolled. All patients had PET/computed tomography (CT) scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to International Harmonization Project criteria (IHP), Deauville 5-point scale (D 5PS) with scores 1-3 considered negative (D 5PS>3) and D 5PS with scores 1-4 considered negative (D 5PS = 5). Ratios of tumor maximum standardized uptake value (SUVmax) to liver SUVmax were also analyzed. We found no difference in progression-free survival (PFS) between PET-negative and PET-positive patients according to IHP and D 5PS>3. The 2-year PFS using D 5PS = 5 was 50.9% in the PET-positive group and 84.8% in the PET-negative group (p = 0.002). A tumor/liver SUVmax cut-off of 3.1 to distinguish D 5PS scores of 4 and 5 provided the best prognostic value. PET after one course of chemotherapy was not able to safely discriminate PET-positive and PET-negative patients in different prognostic groups.",

keywords = "Deauville 5-point scale, diffuse large B-cell lymphoma, predictive value, Interim PET/CT",

author = "Mylam, {Karen Juul} and Lale Kostakoglu and Martin Hutchings and Morton Coleman and Dominick Lamonica and Czuczman, {Myron S.} and Diehl, {Louis F.} and Nielsen, {Anne L.} and Paw Jensen and Annika Loft and Hendel, {Helle W.} and Victor Iyer and Sirpa Leppa and Sirkku Jyrkkio and Harald Holte and Mikael Eriksson and Dorte Gillstrom and Hansen, {Per B.} and Marko Seppanen and Karin Hjorthaug and Brown, {Peter de Nully} and Pedersen, {Lars M.}",

year = "2015",

doi = "10.3109/10428194.2014.975800",

language = "English",

volume = "56",

pages = "2005--2012",

journal = "Leukemia & Lymphoma",

issn = "1042-8194",

publisher = "Taylor & Francis",

number = "7",

}

Mylam, KJ, Kostakoglu, L, Hutchings, M, Coleman, M, Lamonica, D, Czuczman, MS, Diehl, LF, Nielsen, AL, Jensen, P, Loft, A, Hendel, HW, Iyer, V, Leppa, S, Jyrkkio, S, Holte, H, Eriksson, M, Gillstrom, D, Hansen, PB, Seppanen, M, Hjorthaug, K, Brown, PDN & Pedersen, LM 2015, 'F-18-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study', Leukemia & Lymphoma, vol. 56, no. 7, pp. 2005-2012. https://doi.org/10.3109/10428194.2014.975800

F-18-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study. / Mylam, Karen Juul; Kostakoglu, Lale; Hutchings, Martin et al.
In: Leukemia & Lymphoma, Vol. 56, No. 7, 2015, p. 2005-2012.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - F-18-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study

AU - Mylam, Karen Juul

AU - Kostakoglu, Lale

AU - Hutchings, Martin

AU - Coleman, Morton

AU - Lamonica, Dominick

AU - Czuczman, Myron S.

AU - Diehl, Louis F.

AU - Nielsen, Anne L.

AU - Jensen, Paw

AU - Loft, Annika

AU - Hendel, Helle W.

AU - Iyer, Victor

AU - Leppa, Sirpa

AU - Jyrkkio, Sirkku

AU - Holte, Harald

AU - Eriksson, Mikael

AU - Gillstrom, Dorte

AU - Hansen, Per B.

AU - Seppanen, Marko

AU - Hjorthaug, Karin

AU - Brown, Peter de Nully

AU - Pedersen, Lars M.

PY - 2015

Y1 - 2015

N2 - We evaluated the predictive value of interim positon emission tomography (I-PET) after one course of chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients with DLBCL were enrolled. All patients had PET/computed tomography (CT) scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to International Harmonization Project criteria (IHP), Deauville 5-point scale (D 5PS) with scores 1-3 considered negative (D 5PS>3) and D 5PS with scores 1-4 considered negative (D 5PS = 5). Ratios of tumor maximum standardized uptake value (SUVmax) to liver SUVmax were also analyzed. We found no difference in progression-free survival (PFS) between PET-negative and PET-positive patients according to IHP and D 5PS>3. The 2-year PFS using D 5PS = 5 was 50.9% in the PET-positive group and 84.8% in the PET-negative group (p = 0.002). A tumor/liver SUVmax cut-off of 3.1 to distinguish D 5PS scores of 4 and 5 provided the best prognostic value. PET after one course of chemotherapy was not able to safely discriminate PET-positive and PET-negative patients in different prognostic groups.

AB - We evaluated the predictive value of interim positon emission tomography (I-PET) after one course of chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients with DLBCL were enrolled. All patients had PET/computed tomography (CT) scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to International Harmonization Project criteria (IHP), Deauville 5-point scale (D 5PS) with scores 1-3 considered negative (D 5PS>3) and D 5PS with scores 1-4 considered negative (D 5PS = 5). Ratios of tumor maximum standardized uptake value (SUVmax) to liver SUVmax were also analyzed. We found no difference in progression-free survival (PFS) between PET-negative and PET-positive patients according to IHP and D 5PS>3. The 2-year PFS using D 5PS = 5 was 50.9% in the PET-positive group and 84.8% in the PET-negative group (p = 0.002). A tumor/liver SUVmax cut-off of 3.1 to distinguish D 5PS scores of 4 and 5 provided the best prognostic value. PET after one course of chemotherapy was not able to safely discriminate PET-positive and PET-negative patients in different prognostic groups.

KW - Deauville 5-point scale

KW - diffuse large B-cell lymphoma

KW - predictive value

KW - Interim PET/CT

U2 - 10.3109/10428194.2014.975800

DO - 10.3109/10428194.2014.975800

M3 - Article

C2 - 25330442

SN - 1042-8194

VL - 56

SP - 2005

EP - 2012

JO - Leukemia & Lymphoma

JF - Leukemia & Lymphoma

IS - 7

ER -

F-18-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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