Factor V Q506 (resistance to activated protein C) and prognosis after acute coronary syndrome

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12 Citations (SciVal)

Abstract

Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The effect of the FV:Q506 allele on clinical outcome in acute coronary syndrome has not previously been described. Our results demonstrate a gene-environment interaction between smoking and the FV:Q506 allele, with an increased risk of early complications after an acute ischemic event.
Original languageEnglish
Pages (from-to)857-860
Number of pages4
JournalThrombosis and Haemostasis
Volume81
Issue number6
Publication statusPublished - 1999

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Internal Medicine Research Unit (013242520), Clinical Chemistry, Malmö (013016000), Clinical Coagulation Research Unit (013242510), Emergency medicine/Medicine/Surgery (013240200)

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems

Keywords

  • Activated Protein C Resistance
  • Acute Disease
  • Aged
  • Alleles
  • Coronary Disease
  • Factor V
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Polymorphism, Genetic
  • Prevalence
  • Prognosis
  • Risk Factors
  • Journal Article
  • Research Support, Non-U.S. Gov't

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