Abstract
Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The effect of the FV:Q506 allele on clinical outcome in acute coronary syndrome has not previously been described. Our results demonstrate a gene-environment interaction between smoking and the FV:Q506 allele, with an increased risk of early complications after an acute ischemic event.
| Original language | English |
|---|---|
| Pages (from-to) | 857-860 |
| Number of pages | 4 |
| Journal | Thrombosis and Haemostasis |
| Volume | 81 |
| Issue number | 6 |
| Publication status | Published - 1999 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Internal Medicine Research Unit (013242520), Clinical Chemistry, Malmö (013016000), Clinical Coagulation Research Unit (013242510), Emergency medicine/Medicine/Surgery (013240200)
Subject classification (UKÄ)
- Cardiology and Cardiovascular Disease
Free keywords
- Activated Protein C Resistance
- Acute Disease
- Aged
- Alleles
- Coronary Disease
- Factor V
- Female
- Humans
- Male
- Middle Aged
- Mutation
- Polymorphism, Genetic
- Prevalence
- Prognosis
- Risk Factors
- Journal Article
- Research Support, Non-U.S. Gov't