Familial colorectal cancer type X: genetic profiles and phenotypic features.

Mev Dominguez, Christina Therkildsen, Sabrina Da Silva, Mef Nilbert

Research output: Contribution to journalArticlepeer-review

34 Citations (SciVal)


Heredity is a major cause of colorectal cancer, but although several rare high-risk syndromes have been linked to disease-predisposing mutations, the genetic mechanisms are undetermined in the majority of families suspected of hereditary cancer. We review the clinical presentation, histopathologic features, and the genetic and epigenetic profiles of the familial colorectal cancer type X (FCCTX) syndrome with the aim to delineate tumor characteristics that may contribute to refined diagnostics and optimized tumor prevention.Modern Pathology advance online publication, 18 April 2014; doi:10.1038/modpathol.2014.49.
Original languageEnglish
Pages (from-to)30-36
JournalModern Pathology
Issue number1
Publication statusPublished - 2015

Subject classification (UKÄ)

  • Cancer and Oncology


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