Familial colorectal cancer type X: genetic profiles and phenotypic features.

Mev Dominguez; Christina Therkildsen; Sabrina Da Silva; Mef Nilbert

doi:10.1038/modpathol.2014.49

Familial colorectal cancer type X: genetic profiles and phenotypic features.

Mev Dominguez, Christina Therkildsen, Sabrina Da Silva, Mef Nilbert

Research output: Contribution to journal › Article › peer-review

Abstract

Heredity is a major cause of colorectal cancer, but although several rare high-risk syndromes have been linked to disease-predisposing mutations, the genetic mechanisms are undetermined in the majority of families suspected of hereditary cancer. We review the clinical presentation, histopathologic features, and the genetic and epigenetic profiles of the familial colorectal cancer type X (FCCTX) syndrome with the aim to delineate tumor characteristics that may contribute to refined diagnostics and optimized tumor prevention.Modern Pathology advance online publication, 18 April 2014; doi:10.1038/modpathol.2014.49.

Original language	English
Pages (from-to)	30-36
Journal	Modern Pathology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1038/modpathol.2014.49
Publication status	Published - 2015

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/modpathol.2014.49

http://www.ncbi.nlm.nih.gov/pubmed/24743215?dopt=Abstract

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Precision Medicine in Hereditary Cancer and Sarcoma; targeted surveillance, immunotherapy and individualized follow-up
Nilbert, M. (PI), Rambech, E. (Researcher), Jönsson, M. (Researcher), Styring, E. (Assistant supervisor), Nyström, H. (Research student) & Rosell, L. (Research student)
Project: Research
Precision Medicine in Hereditary Cancer and Sarcoma; targeted surveillance, immunotherapy and individualized follow-up
Nilbert, M. (PI), Nyström, H. (Research student), Rosell, L. (Research student), Jönsson, M. (Researcher), Rambech, E. (Researcher), Peterson, S. (CoI) & Styring, E. (Assistant supervisor)
2017/01/01 → 2018/12/31
Project: Research

Cite this

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abstract = "Heredity is a major cause of colorectal cancer, but although several rare high-risk syndromes have been linked to disease-predisposing mutations, the genetic mechanisms are undetermined in the majority of families suspected of hereditary cancer. We review the clinical presentation, histopathologic features, and the genetic and epigenetic profiles of the familial colorectal cancer type X (FCCTX) syndrome with the aim to delineate tumor characteristics that may contribute to refined diagnostics and optimized tumor prevention.Modern Pathology advance online publication, 18 April 2014; doi:10.1038/modpathol.2014.49.",

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AB - Heredity is a major cause of colorectal cancer, but although several rare high-risk syndromes have been linked to disease-predisposing mutations, the genetic mechanisms are undetermined in the majority of families suspected of hereditary cancer. We review the clinical presentation, histopathologic features, and the genetic and epigenetic profiles of the familial colorectal cancer type X (FCCTX) syndrome with the aim to delineate tumor characteristics that may contribute to refined diagnostics and optimized tumor prevention.Modern Pathology advance online publication, 18 April 2014; doi:10.1038/modpathol.2014.49.

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Familial colorectal cancer type X: genetic profiles and phenotypic features.

Abstract

Subject classification (UKÄ)

UN SDGs

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Projects

Precision Medicine in Hereditary Cancer and Sarcoma; targeted surveillance, immunotherapy and individualized follow-up

Precision Medicine in Hereditary Cancer and Sarcoma; targeted surveillance, immunotherapy and individualized follow-up

Cite this