Fatty Acid Profiles in Smokers with Chronic Periodontitis

N. Buduneli, Lennart Larsson, B. Biyikoglu, D. E. Renaud, J. Bagaitkar, D. A. Scott

Research output: Contribution to journalArticlepeer-review

8 Citations (SciVal)

Abstract

We hypothesized that tobacco smoke induces alterations to the 3-OH fatty acids present in lipid A in a manner consistent with a microflora of reduced inflammatory potential. Whole saliva samples and full-mouth clinical periodontal recordings were obtained from persons with (22 smokers; 15 nonsmokers) and without (14 smokers; 15 non-smokers) chronic periodontitis. Clear differences in the contributions of multiple saturated 3-OH fatty acid species were noted in the group with disease compared with healthy individuals. Increases in the long-chain fatty acids associated with anaerobic bacterial periodontopathogens, particularly 3-OH-C-i17.0 (146.7%, relative to controls), were apparent. Significant reductions in the 3-OH fatty acids associated with the consensus (high potency) enteric LPS structure (3-OH-C-12.0 and 3-OH-C-14.0; 33.3% and 15.8% reduction, respectively) were noted in smokers compared with non-smokers with chronic periodontitis. Thus, smoking is associated with specific structural alterations to the lipid-A-derived 3-OH fatty acid profile in saliva that are consistent with an oral microflora of reduced inflammatory potential. These findings provide much-needed mechanistic insight into the established clinical conundrum of increased infection with periodontal pathogens but reduced clinical inflammation in smokers.
Original languageEnglish
Pages (from-to)47-52
JournalJournal of Dental Research
Volume90
Issue number1
DOIs
Publication statusPublished - 2011

Subject classification (UKÄ)

  • Dentistry

Keywords

  • inflammation
  • lipid A
  • lipopolysaccharide
  • periodontitis
  • saliva
  • smoking

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