Abstract
Abstract Background: Cord artery protein S-100 levels at birth are potential markers of brain damage after asphyxia. Our aim was to investigate if S-100 levels were elevated in neonates with indirect signs of asphyxia during birth. S-100 levels in cord blood were studied in relation to cardiotocography (CTG) and fetal electrocardiography (FECG) changes during birth and to acidemia in umbilical blood. Material and methods: This case-control study was performed in parallel to a large randomized controlled trial (RCT) studying FECG at birth. Protein S-100 samples were collected from 103 neonates at birth and related to the CTG and ECG changes during labor and to pH in umbilical blood. Results: Protein S-100 was significantly higher in neonates with umbilical artery blood pH</=7.05, compared to neonates with pH>7.05. Furthermore, neonates with preterminal CTG patterns showed increased S-100 levels compared to neonates with normal CTG. Neonates having significant CTG and ECG changes, leading to intervention according to clinical guidelines, showed significantly higher S-100 levels compared to neonates without such indication of intervention. Conclusion: A relation exists between S-100 in umbilical blood at birth, acidosis and pathological patterns in CTG and FECG during labor.
Original language | English |
---|---|
Pages (from-to) | 136-141 |
Journal | Journal of Perinatal Medicine |
Volume | 36 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2008 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Reproductive Epidemiology/Tornblad Institute (013003000), Research Unit for Urogynaecology and Reproductive Pharmacology (013242710), Department of Obstetrics and Gynaecology (Lund) (013018000)
Subject classification (UKÄ)
- Pediatrics