Fiber optic system for in vivo real-time determination of tissue optical properties from steady-state diffuse reflectance measurements

J. S Dam, C. B Pedersen, P. E Fabricius, Stefan Andersson-Engels

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Abstract

We present a versatile and compact fiber optic probe for real-time determination of the absorption and the reduced scattering coefficients from spatially resolved continuous wave diffuse reflectance measurements. The probe collects the diffuse reflectance at six distances in the range 0.6 - 7.8 mm at four arbitrary wavelengths, which were 660, 785, 805, and 974 nm in these experiments. The maximum sampling rate for one cycle of measurements including all four wavelengths is about 100 Hz. The absorption and the reduced scattering coefficients are extracted real-time from the probe measurements using multivariate calibration methods based on multiple polynomial regression and Newton-Raphson algorithms. The system was calibrated on a 6x7 matrix of Intralipid/ink phantoms with optical properties within typical biological ranges, e.g. at 785 nm, the ranges of the absorption and the reduced scattering coefficients, were 0 - 0.3 /cm and 6 - 16 /cm, respectively. Cross-validation tests shoved that the mean prediction error, relative to the ranges of absorption and the reduced scattering coefficients were 2.8 \% and 1.3 \%, respectively.
Original languageEnglish
Title of host publicationPHOTON MIGRATION, DIFFUSE SPECTROSCOPY AND OPTICAL COHERENCE TOMOGRAPHY: IMAGING AND FUNCTIONAL ASSESSMENT
EditorsS Andersson-Engels, JG Fujimoto
PublisherSPIE
Pages103-109
Volume1
ISBN (Print)0-8194-3816-2
DOIs
Publication statusPublished - 2000
EventConference on Photon Migration, Diffuse Spectroscopy, and Optical Coherence Tomography, 2000 - Amsterdam, Netherlands
Duration: 2000 Jul 62000 Jul 8

Publication series

Name
Number31
Volume1
ISSN (Print)1996-756X
ISSN (Electronic)0277-786X

Conference

ConferenceConference on Photon Migration, Diffuse Spectroscopy, and Optical Coherence Tomography, 2000
Country/TerritoryNetherlands
CityAmsterdam
Period2000/07/062000/07/08

Subject classification (UKÄ)

  • Atom and Molecular Physics and Optics

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