Fifteen-Piconewton Force Detection from Neural Growth Cones Using Nanowire Arrays

Waldemar Hällström; Monica Lexholm; Dmitry Suyatin; Greger Hammarin; Dan Hessman; Lars Samuelson; Lars Montelius; Martin Kanje; Christelle Prinz

doi:10.1021/nl902675h

Fifteen-Piconewton Force Detection from Neural Growth Cones Using Nanowire Arrays

Waldemar Hällström, Monica Lexholm, Dmitry Suyatin, Greger Hammarin, Dan Hessman, Lars Samuelson, Lars Montelius, Martin Kanje, Christelle Prinz

Research output: Contribution to journal › Article › peer-review

Abstract

We used epitaxially grown monodisperse nanowire arrays to measure cellular forces with a spatial resolution of 1 mu m. Nerve cells were cultured on the array and cellular forces were calculated from the displacement of the nanowire tips. The measurements were done in situ on live cells using confocal microscopy, Forces down to 15 pN were measured on neural growth cones, showing that this method can be used to study the Fine details of growth-cone dynamics.

Original language	English
Pages (from-to)	782-787
Journal	Nano Letters
Volume	10
Issue number	3
DOIs	https://doi.org/10.1021/nl902675h
Publication status	Published - 2010

Subject classification (UKÄ)

Nano-technology

Free keywords

neuron
nanowire
picoNewton
Mechanosensing
cellular force

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10.1021/nl902675h

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title = "Fifteen-Piconewton Force Detection from Neural Growth Cones Using Nanowire Arrays",

abstract = "We used epitaxially grown monodisperse nanowire arrays to measure cellular forces with a spatial resolution of 1 mu m. Nerve cells were cultured on the array and cellular forces were calculated from the displacement of the nanowire tips. The measurements were done in situ on live cells using confocal microscopy, Forces down to 15 pN were measured on neural growth cones, showing that this method can be used to study the Fine details of growth-cone dynamics.",

keywords = "neuron, nanowire, picoNewton, Mechanosensing, cellular force",

author = "Waldemar H{\"a}llstr{\"o}m and Monica Lexholm and Dmitry Suyatin and Greger Hammarin and Dan Hessman and Lars Samuelson and Lars Montelius and Martin Kanje and Christelle Prinz",

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language = "English",

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TY - JOUR

T1 - Fifteen-Piconewton Force Detection from Neural Growth Cones Using Nanowire Arrays

AU - Hällström, Waldemar

AU - Lexholm, Monica

AU - Suyatin, Dmitry

AU - Hammarin, Greger

AU - Hessman, Dan

AU - Samuelson, Lars

AU - Montelius, Lars

AU - Kanje, Martin

AU - Prinz, Christelle

PY - 2010

Y1 - 2010

N2 - We used epitaxially grown monodisperse nanowire arrays to measure cellular forces with a spatial resolution of 1 mu m. Nerve cells were cultured on the array and cellular forces were calculated from the displacement of the nanowire tips. The measurements were done in situ on live cells using confocal microscopy, Forces down to 15 pN were measured on neural growth cones, showing that this method can be used to study the Fine details of growth-cone dynamics.

AB - We used epitaxially grown monodisperse nanowire arrays to measure cellular forces with a spatial resolution of 1 mu m. Nerve cells were cultured on the array and cellular forces were calculated from the displacement of the nanowire tips. The measurements were done in situ on live cells using confocal microscopy, Forces down to 15 pN were measured on neural growth cones, showing that this method can be used to study the Fine details of growth-cone dynamics.

KW - neuron

KW - nanowire

KW - picoNewton

KW - Mechanosensing

KW - cellular force

U2 - 10.1021/nl902675h

DO - 10.1021/nl902675h

M3 - Article

C2 - 20102185

SN - 1530-6992

VL - 10

SP - 782

EP - 787

JO - Nano Letters

JF - Nano Letters

IS - 3

ER -

Fifteen-Piconewton Force Detection from Neural Growth Cones Using Nanowire Arrays

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Subject classification (UKÄ)

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