Filoviruses belong to the group of nonsegmented, negative-sense (NNS) RNA viruses and are members of the order Mononegavirales along with the rhabdo-, paramyxo-, nyami-, and bornaviruses. Mononegaviruses share a general mechanism to replicate and transcribe their genomes, reflected in functionally homologous proteins and a similar genome structure. Although basic mechanisms are similar between rhabdo- and filoviral RNA synthesis, both virus families have developed distinct features. In this chapter, we describe the concepts underlying filovirus replication and transcription. We introduce the technologies that have enabled scientists to decipher the viral replication cycle and discuss recent insights in the regulation of filoviral RNA synthesis. We also highlight differences in RNA synthesis between filoviruses and two widely studied rhabdoviruses, vesicular stomatitis virus (VSV) of the Vesiculovirus genus and rabies virus (RABV) of the Lyssavirus genus.
|Title of host publication||Biology and Pathogenesis of Rhabdo-and Filoviruses|
|Editors||A K Pattnaik, M A Whitt|
|Publisher||World Scientific Publishing|
|ISBN (Print)||978-981-4635-33-2, 978-981-4635-35-6|
|Publication status||Published - 2015|
Subject classification (UKÄ)