Fine needle aspiration diagnosis of spindle cell tumors of soft tissue, including the use of ancillary methods, and correlation with clinical data.

Henryk Domanski

Fine needle aspiration diagnosis of spindle cell tumors of soft tissue, including the use of ancillary methods, and correlation with clinical data.

Henryk Domanski

Tumor microenvironment

Research output: Thesis › Doctoral Thesis (compilation)

Abstract

Fine needle aspiration cytology (FNAC) is gaining increased popularity in the diagnosis of soft tissue lesions. FNAC used as a primary examination method to obtain a morphologic diagnosis, has been part of the diagnostic work-up of patients admitted to the Musculoskeletal Tumor Center of the Lund University Hospital since 1972. Accuracy of FNAC in distinguishing benign from malignant soft tissue tumors has been comparable to that of surgical biopsies, while its accuracy in establishing a specific subtype diagnosis has been inferior to surgical biopsies.

The cytological examination of spindle cell tumors of soft tissue, which often share morphological and clinical characteristics, is a challenge. In addition, the literature on FNAC of spindle cell tumors is still sparse.

The purpose of this study was both to describe the spectrum of FNAC findings in spindle cell tumors of soft tissue and also to analyze which ancillary methods can optimize FNA cytodiagnosis among these tumors in order to minimize the need for open biopsy.

To this end, 238 FNA aspirates performed on 236 patients with five selected types of spindle cell tumors of soft tissue were analysed. In addition, clinical information and ancillary studies, which could increase the precision of cytodiagnosis were evaluated.

The results of the study indicate the following:

Different treatment options for some low grade and local aggressive/benign spindle cell tumors require an exact histotype diagnosis. This can be usually obtained from aspiration smears complemented by clinical data in elastofibroma dorsi and spindle cell lipoma due to their characteristic cytomorphology. FNAC evaluation of neurilemoma (schwannoma), leiomyosarcoma and dermatofibrosarcoma protuberans, requires the use of strict cytological criteria together with proper clinical information and often ancillary techniques.

Correct cytologic diagnosis of spindle cell tumors is facilitated when fine needle aspiration cytology is used in the context of the clinical findings and when the cytological diagnosis is based on strict cytological criteria as well as ancillary techniques.

Original language	English
Qualification	Doctor
Awarding Institution	Tumor microenvironment
Supervisors/Advisors	Alm, Per, Supervisor
Award date	2005 Dec 16
Publisher	Department of Patology & Cytology Lund University Hospital 221 85 Lund Sweden
ISBN (Print)	91-85481-21-1
Publication status	Published - 2005

Bibliographical note

Defence details

Date: 2005-12-16
Time: 13:00
Place: Föreläsningssalen, Patologiska/Cytologiska kliniken, Universitetssjukhuset, Lund.

External reviewer(s)

Name: Hagmar, Björn
Title: Professor
Affiliation: Oslo, Norge

---

<div class="article_info">HA Domanski, B Carlén, K Jonsson, F Mertens and M Åkerman. <span class="article_issue_date">2001</span>. <span class="article_title">Distinct cytologic features of spindle cell lipoma. A cytologic-histologic study with clinical, radiologic, electron microscopic and cytogenetic correlations.</span> <span class="journal_series_title">Cancer</span>, <span class="journal_volume">vol 93</span> <span class="journal_pages">pp 381-389</span>.</div>
<div class="article_info">HA Domanski and P Gustafson. <span class="article_issue_date">2002</span>. <span class="article_title">Cytologic features of primary, recurrent, and metastatic dermatofibrosarcoma protuberans.</span> <span class="journal_series_title">Cancer</span>, <span class="journal_volume">vol 96</span> <span class="journal_pages">pp 351-361</span>.</div>
<div class="article_info">HA Domanski. <span class="article_issue_date">2005</span>. <span class="article_title">FNA diagnosis of dermatofibrosarcoma protuberans.</span> <span class="journal_series_title">Diagn Cytopathol</span>, <span class="journal_volume">vol 32</span> <span class="journal_pages">pp 299-302</span>.</div>
<div class="article_info">HA Domanski, B Carlén, M Sloth and A Rydholm. <span class="article_issue_date">2003</span>. <span class="article_title">Elastofibroma dorsi has distinct cytomorphologic features making diagnostic surgical biopsy unnecessary: a cytomorphologic study with clinical, radiological and electron microscopic correlations.</span> <span class="journal_series_title">Diagn Cytopathol</span>, <span class="journal_volume">vol 29</span> <span class="journal_pages">pp 327-333</span>.</div>
<div class="article_info">HA Domanski, M Åkerman, J Engellau, P Gustafson, F Mertens and A Rydholm. <span class="article_issue_date"></span>. <span class="article_title">Fine-needle aspiration of neurilemoma. A clinicocytopathologic study of 116 patients.</span> (accepted)</div>
<div class="article_info">HA Domanski, M Åkerman, P Rissler and P Gustafson. <span class="article_issue_date"></span>. <span class="article_title">Fine needle aspiration of soft tissue leiomyosarcoma. An analysis of the most common cytologic findings and the value of ancillary techniques.</span> (submitted)</div>

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pathology, (Lund) (013030000)

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

Patologi (allmän)
patologisk anatomi
General pathology
pathological anatomy
spindle cell lipoma
soft tissue
spindle cell tumors
Medicine (human and vertebrates)
Medicin (människa och djur)
schwannoma
neurilemoma
leiomyosarcoma
immunocytochemistry
FNA
fine needle aspiration
dermatofibrosarcoma protuberans
elastofibroma dorsi
Cytology
electron microscopy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@phdthesis{5ee64f706acd449e87eea3f583c30f7c,

title = "Fine needle aspiration diagnosis of spindle cell tumors of soft tissue, including the use of ancillary methods, and correlation with clinical data.",

abstract = "Fine needle aspiration cytology (FNAC) is gaining increased popularity in the diagnosis of soft tissue lesions. FNAC used as a primary examination method to obtain a morphologic diagnosis, has been part of the diagnostic work-up of patients admitted to the Musculoskeletal Tumor Center of the Lund University Hospital since 1972. Accuracy of FNAC in distinguishing benign from malignant soft tissue tumors has been comparable to that of surgical biopsies, while its accuracy in establishing a specific subtype diagnosis has been inferior to surgical biopsies. The cytological examination of spindle cell tumors of soft tissue, which often share morphological and clinical characteristics, is a challenge. In addition, the literature on FNAC of spindle cell tumors is still sparse. The purpose of this study was both to describe the spectrum of FNAC findings in spindle cell tumors of soft tissue and also to analyze which ancillary methods can optimize FNA cytodiagnosis among these tumors in order to minimize the need for open biopsy. To this end, 238 FNA aspirates performed on 236 patients with five selected types of spindle cell tumors of soft tissue were analysed. In addition, clinical information and ancillary studies, which could increase the precision of cytodiagnosis were evaluated. The results of the study indicate the following: Different treatment options for some low grade and local aggressive/benign spindle cell tumors require an exact histotype diagnosis. This can be usually obtained from aspiration smears complemented by clinical data in elastofibroma dorsi and spindle cell lipoma due to their characteristic cytomorphology. FNAC evaluation of neurilemoma (schwannoma), leiomyosarcoma and dermatofibrosarcoma protuberans, requires the use of strict cytological criteria together with proper clinical information and often ancillary techniques. Correct cytologic diagnosis of spindle cell tumors is facilitated when fine needle aspiration cytology is used in the context of the clinical findings and when the cytological diagnosis is based on strict cytological criteria as well as ancillary techniques.",

keywords = "Patologi (allm{\"a}n), patologisk anatomi, General pathology, pathological anatomy, spindle cell lipoma, soft tissue, spindle cell tumors, Medicine (human and vertebrates), Medicin (m{\"a}nniska och djur), schwannoma, neurilemoma, leiomyosarcoma, immunocytochemistry, FNA, fine needle aspiration, dermatofibrosarcoma protuberans, elastofibroma dorsi, Cytology, electron microscopy",

author = "Henryk Domanski",

note = "Defence details Date: 2005-12-16 Time: 13:00 Place: F{\"o}rel{\"a}sningssalen, Patologiska/Cytologiska kliniken, Universitetssjukhuset, Lund. External reviewer(s) Name: Hagmar, Bj{\"o}rn Title: Professor Affiliation: Oslo, Norge --- <div class={"}article\_info{"}>HA Domanski, B Carl{\'e}n, K Jonsson, F Mertens and M {\AA}kerman. <span class={"}article\_issue\_date{"}>2001</span>. <span class={"}article\_title{"}>Distinct cytologic features of spindle cell lipoma. A cytologic-histologic study with clinical, radiologic, electron microscopic and cytogenetic correlations.</span> <span class={"}journal\_series\_title{"}>Cancer</span>, <span class={"}journal\_volume{"}>vol 93</span> <span class={"}journal\_pages{"}>pp 381-389</span>.</div> <div class={"}article\_info{"}>HA Domanski and P Gustafson. <span class={"}article\_issue\_date{"}>2002</span>. <span class={"}article\_title{"}>Cytologic features of primary, recurrent, and metastatic dermatofibrosarcoma protuberans.</span> <span class={"}journal\_series\_title{"}>Cancer</span>, <span class={"}journal\_volume{"}>vol 96</span> <span class={"}journal\_pages{"}>pp 351-361</span>.</div> <div class={"}article\_info{"}>HA Domanski. <span class={"}article\_issue\_date{"}>2005</span>. <span class={"}article\_title{"}>FNA diagnosis of dermatofibrosarcoma protuberans.</span> <span class={"}journal\_series\_title{"}>Diagn Cytopathol</span>, <span class={"}journal\_volume{"}>vol 32</span> <span class={"}journal\_pages{"}>pp 299-302</span>.</div> <div class={"}article\_info{"}>HA Domanski, B Carl{\'e}n, M Sloth and A Rydholm. <span class={"}article\_issue\_date{"}>2003</span>. <span class={"}article\_title{"}>Elastofibroma dorsi has distinct cytomorphologic features making diagnostic surgical biopsy unnecessary: a cytomorphologic study with clinical, radiological and electron microscopic correlations.</span> <span class={"}journal\_series\_title{"}>Diagn Cytopathol</span>, <span class={"}journal\_volume{"}>vol 29</span> <span class={"}journal\_pages{"}>pp 327-333</span>.</div> <div class={"}article\_info{"}>HA Domanski, M {\AA}kerman, J Engellau, P Gustafson, F Mertens and A Rydholm. <span class={"}article\_issue\_date{"}></span>. <span class={"}article\_title{"}>Fine-needle aspiration of neurilemoma. A clinicocytopathologic study of 116 patients.</span> (accepted)</div> <div class={"}article\_info{"}>HA Domanski, M {\AA}kerman, P Rissler and P Gustafson. <span class={"}article\_issue\_date{"}></span>. <span class={"}article\_title{"}>Fine needle aspiration of soft tissue leiomyosarcoma. An analysis of the most common cytologic findings and the value of ancillary techniques.</span> (submitted)</div> The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)",

year = "2005",

language = "English",

isbn = "91-85481-21-1",

publisher = "Department of Patology \& Cytology Lund University Hospital 221 85 Lund Sweden",

type = "Doctoral Thesis (compilation)",

school = "Tumor microenvironment",

}

TY - THES

T1 - Fine needle aspiration diagnosis of spindle cell tumors of soft tissue, including the use of ancillary methods, and correlation with clinical data.

AU - Domanski, Henryk

N1 - Defence details Date: 2005-12-16 Time: 13:00 Place: Föreläsningssalen, Patologiska/Cytologiska kliniken, Universitetssjukhuset, Lund. External reviewer(s) Name: Hagmar, Björn Title: Professor Affiliation: Oslo, Norge --- <div class="article_info">HA Domanski, B Carlén, K Jonsson, F Mertens and M Åkerman. <span class="article_issue_date">2001</span>. <span class="article_title">Distinct cytologic features of spindle cell lipoma. A cytologic-histologic study with clinical, radiologic, electron microscopic and cytogenetic correlations.</span> <span class="journal_series_title">Cancer</span>, <span class="journal_volume">vol 93</span> <span class="journal_pages">pp 381-389</span>.</div> <div class="article_info">HA Domanski and P Gustafson. <span class="article_issue_date">2002</span>. <span class="article_title">Cytologic features of primary, recurrent, and metastatic dermatofibrosarcoma protuberans.</span> <span class="journal_series_title">Cancer</span>, <span class="journal_volume">vol 96</span> <span class="journal_pages">pp 351-361</span>.</div> <div class="article_info">HA Domanski. <span class="article_issue_date">2005</span>. <span class="article_title">FNA diagnosis of dermatofibrosarcoma protuberans.</span> <span class="journal_series_title">Diagn Cytopathol</span>, <span class="journal_volume">vol 32</span> <span class="journal_pages">pp 299-302</span>.</div> <div class="article_info">HA Domanski, B Carlén, M Sloth and A Rydholm. <span class="article_issue_date">2003</span>. <span class="article_title">Elastofibroma dorsi has distinct cytomorphologic features making diagnostic surgical biopsy unnecessary: a cytomorphologic study with clinical, radiological and electron microscopic correlations.</span> <span class="journal_series_title">Diagn Cytopathol</span>, <span class="journal_volume">vol 29</span> <span class="journal_pages">pp 327-333</span>.</div> <div class="article_info">HA Domanski, M Åkerman, J Engellau, P Gustafson, F Mertens and A Rydholm. <span class="article_issue_date"></span>. <span class="article_title">Fine-needle aspiration of neurilemoma. A clinicocytopathologic study of 116 patients.</span> (accepted)</div> <div class="article_info">HA Domanski, M Åkerman, P Rissler and P Gustafson. <span class="article_issue_date"></span>. <span class="article_title">Fine needle aspiration of soft tissue leiomyosarcoma. An analysis of the most common cytologic findings and the value of ancillary techniques.</span> (submitted)</div> The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)

PY - 2005

Y1 - 2005

N2 - Fine needle aspiration cytology (FNAC) is gaining increased popularity in the diagnosis of soft tissue lesions. FNAC used as a primary examination method to obtain a morphologic diagnosis, has been part of the diagnostic work-up of patients admitted to the Musculoskeletal Tumor Center of the Lund University Hospital since 1972. Accuracy of FNAC in distinguishing benign from malignant soft tissue tumors has been comparable to that of surgical biopsies, while its accuracy in establishing a specific subtype diagnosis has been inferior to surgical biopsies. The cytological examination of spindle cell tumors of soft tissue, which often share morphological and clinical characteristics, is a challenge. In addition, the literature on FNAC of spindle cell tumors is still sparse. The purpose of this study was both to describe the spectrum of FNAC findings in spindle cell tumors of soft tissue and also to analyze which ancillary methods can optimize FNA cytodiagnosis among these tumors in order to minimize the need for open biopsy. To this end, 238 FNA aspirates performed on 236 patients with five selected types of spindle cell tumors of soft tissue were analysed. In addition, clinical information and ancillary studies, which could increase the precision of cytodiagnosis were evaluated. The results of the study indicate the following: Different treatment options for some low grade and local aggressive/benign spindle cell tumors require an exact histotype diagnosis. This can be usually obtained from aspiration smears complemented by clinical data in elastofibroma dorsi and spindle cell lipoma due to their characteristic cytomorphology. FNAC evaluation of neurilemoma (schwannoma), leiomyosarcoma and dermatofibrosarcoma protuberans, requires the use of strict cytological criteria together with proper clinical information and often ancillary techniques. Correct cytologic diagnosis of spindle cell tumors is facilitated when fine needle aspiration cytology is used in the context of the clinical findings and when the cytological diagnosis is based on strict cytological criteria as well as ancillary techniques.

AB - Fine needle aspiration cytology (FNAC) is gaining increased popularity in the diagnosis of soft tissue lesions. FNAC used as a primary examination method to obtain a morphologic diagnosis, has been part of the diagnostic work-up of patients admitted to the Musculoskeletal Tumor Center of the Lund University Hospital since 1972. Accuracy of FNAC in distinguishing benign from malignant soft tissue tumors has been comparable to that of surgical biopsies, while its accuracy in establishing a specific subtype diagnosis has been inferior to surgical biopsies. The cytological examination of spindle cell tumors of soft tissue, which often share morphological and clinical characteristics, is a challenge. In addition, the literature on FNAC of spindle cell tumors is still sparse. The purpose of this study was both to describe the spectrum of FNAC findings in spindle cell tumors of soft tissue and also to analyze which ancillary methods can optimize FNA cytodiagnosis among these tumors in order to minimize the need for open biopsy. To this end, 238 FNA aspirates performed on 236 patients with five selected types of spindle cell tumors of soft tissue were analysed. In addition, clinical information and ancillary studies, which could increase the precision of cytodiagnosis were evaluated. The results of the study indicate the following: Different treatment options for some low grade and local aggressive/benign spindle cell tumors require an exact histotype diagnosis. This can be usually obtained from aspiration smears complemented by clinical data in elastofibroma dorsi and spindle cell lipoma due to their characteristic cytomorphology. FNAC evaluation of neurilemoma (schwannoma), leiomyosarcoma and dermatofibrosarcoma protuberans, requires the use of strict cytological criteria together with proper clinical information and often ancillary techniques. Correct cytologic diagnosis of spindle cell tumors is facilitated when fine needle aspiration cytology is used in the context of the clinical findings and when the cytological diagnosis is based on strict cytological criteria as well as ancillary techniques.

KW - Patologi (allmän)

KW - patologisk anatomi

KW - General pathology

KW - pathological anatomy

KW - spindle cell lipoma

KW - soft tissue

KW - spindle cell tumors

KW - Medicine (human and vertebrates)

KW - Medicin (människa och djur)

KW - schwannoma

KW - neurilemoma

KW - leiomyosarcoma

KW - immunocytochemistry

KW - FNA

KW - fine needle aspiration

KW - dermatofibrosarcoma protuberans

KW - elastofibroma dorsi

KW - Cytology

KW - electron microscopy

M3 - Doctoral Thesis (compilation)

SN - 91-85481-21-1

PB - Department of Patology & Cytology Lund University Hospital 221 85 Lund Sweden

ER -

Fine needle aspiration diagnosis of spindle cell tumors of soft tissue, including the use of ancillary methods, and correlation with clinical data.

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

UN SDGs

Fingerprint

Cite this