First Administration of the Fc-Attenuated Anti-β Amyloid Antibody GSK933776 to Patients with Mild Alzheimer's Disease: A Randomized, Placebo-Controlled Study.

Niels Andreasen; Monica Simeoni; Henrik Östlund; Pia I Lisjo; Tormod Fladby; Amy E Loercher; Gerard J Byrne; Frances Murray; Paul T Scott-Stevens; Anders Wallin; Yinghua Y Zhang; Lena H Bronge; Henrik Zetterberg; Agneta K Nordberg; Astrid J Yeo; Shahid A Khan; Jan Hilpert; Prafull C Mistry

doi:10.1371/journal.pone.0098153

First Administration of the Fc-Attenuated Anti-β Amyloid Antibody GSK933776 to Patients with Mild Alzheimer's Disease: A Randomized, Placebo-Controlled Study.

Niels Andreasen, Monica Simeoni, Henrik Östlund, Pia I Lisjo, Tormod Fladby, Amy E Loercher, Gerard J Byrne, Frances Murray, Paul T Scott-Stevens, Anders Wallin, Yinghua Y Zhang, Lena H Bronge, Henrik Zetterberg, Agneta K Nordberg, Astrid J Yeo, Shahid A Khan, Jan Hilpert, Prafull C Mistry

Clinical Memory Research

Research output: Contribution to journal › Article › peer-review

Abstract

To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the Fc-inactivated anti-β amyloid (Aβ) monoclonal antibody (mAb) GSK933776 in patients with mild Alzheimer's disease (AD) or mild cognitive impairment (MCI).

Original language	English
Article number	e0098153
Journal	PLoS ONE
Volume	10
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0098153
Publication status	Published - 2015

Subject classification (UKÄ)

Neurology

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10.1371/journal.pone.0098153

http://www.ncbi.nlm.nih.gov/pubmed/25789616?dopt=Abstract

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Andreasen, N., Simeoni, M., Östlund, H., Lisjo, P. I., Fladby, T., Loercher, A. E., Byrne, G. J., Murray, F., Scott-Stevens, P. T., Wallin, A., Zhang, Y. Y., Bronge, L. H., Zetterberg, H., Nordberg, A. K., Yeo, A. J., Khan, S. A., Hilpert, J., & Mistry, P. C. (2015). First Administration of the Fc-Attenuated Anti-β Amyloid Antibody GSK933776 to Patients with Mild Alzheimer's Disease: A Randomized, Placebo-Controlled Study. PLoS ONE, 10(3), Article e0098153. https://doi.org/10.1371/journal.pone.0098153

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title = "First Administration of the Fc-Attenuated Anti-β Amyloid Antibody GSK933776 to Patients with Mild Alzheimer's Disease: A Randomized, Placebo-Controlled Study.",

abstract = "To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the Fc-inactivated anti-β amyloid (Aβ) monoclonal antibody (mAb) GSK933776 in patients with mild Alzheimer's disease (AD) or mild cognitive impairment (MCI).",

author = "Niels Andreasen and Monica Simeoni and Henrik {\"O}stlund and Lisjo, \{Pia I\} and Tormod Fladby and Loercher, \{Amy E\} and Byrne, \{Gerard J\} and Frances Murray and Scott-Stevens, \{Paul T\} and Anders Wallin and Zhang, \{Yinghua Y\} and Bronge, \{Lena H\} and Henrik Zetterberg and Nordberg, \{Agneta K\} and Yeo, \{Astrid J\} and Khan, \{Shahid A\} and Jan Hilpert and Mistry, \{Prafull C\}",

year = "2015",

doi = "10.1371/journal.pone.0098153",

language = "English",

volume = "10",

journal = "PLoS ONE",

issn = "1932-6203",

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}

Andreasen, N, Simeoni, M, Östlund, H, Lisjo, PI, Fladby, T, Loercher, AE, Byrne, GJ, Murray, F, Scott-Stevens, PT, Wallin, A, Zhang, YY, Bronge, LH, Zetterberg, H, Nordberg, AK, Yeo, AJ, Khan, SA, Hilpert, J & Mistry, PC 2015, 'First Administration of the Fc-Attenuated Anti-β Amyloid Antibody GSK933776 to Patients with Mild Alzheimer's Disease: A Randomized, Placebo-Controlled Study.', PLoS ONE, vol. 10, no. 3, e0098153. https://doi.org/10.1371/journal.pone.0098153

TY - JOUR

T1 - First Administration of the Fc-Attenuated Anti-β Amyloid Antibody GSK933776 to Patients with Mild Alzheimer's Disease: A Randomized, Placebo-Controlled Study.

AU - Andreasen, Niels

AU - Simeoni, Monica

AU - Östlund, Henrik

AU - Lisjo, Pia I

AU - Fladby, Tormod

AU - Loercher, Amy E

AU - Byrne, Gerard J

AU - Murray, Frances

AU - Scott-Stevens, Paul T

AU - Wallin, Anders

AU - Zhang, Yinghua Y

AU - Bronge, Lena H

AU - Zetterberg, Henrik

AU - Nordberg, Agneta K

AU - Yeo, Astrid J

AU - Khan, Shahid A

AU - Hilpert, Jan

AU - Mistry, Prafull C

PY - 2015

Y1 - 2015

N2 - To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the Fc-inactivated anti-β amyloid (Aβ) monoclonal antibody (mAb) GSK933776 in patients with mild Alzheimer's disease (AD) or mild cognitive impairment (MCI).

AB - To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the Fc-inactivated anti-β amyloid (Aβ) monoclonal antibody (mAb) GSK933776 in patients with mild Alzheimer's disease (AD) or mild cognitive impairment (MCI).

UR - https://www.scopus.com/pages/publications/84961291985

U2 - 10.1371/journal.pone.0098153

DO - 10.1371/journal.pone.0098153

M3 - Article

C2 - 25789616

SN - 1932-6203

VL - 10

JO - PLoS ONE

JF - PLoS ONE

IS - 3

M1 - e0098153

ER -

First Administration of the Fc-Attenuated Anti-β Amyloid Antibody GSK933776 to Patients with Mild Alzheimer's Disease: A Randomized, Placebo-Controlled Study.

Abstract

Subject classification (UKÄ)

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