First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist

J. Schouenborg; B. H. Sjölund

doi:10.1016/0006-8993(86)90798-5

First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist

J. Schouenborg, B. H. Sjölund

Medical Board of the Armed Forces

Research output: Contribution to journal › Article › peer-review

Abstract

An antagonist to amino acid evoked excitation, γ-d-glutamylglycine (γ-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive afferent C-fibres. These results might be useful for development of centrally acting analgesic drugs.

Original language	English
Pages (from-to)	394-398
Number of pages	5
Journal	Brain Research
Volume	379
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(86)90798-5
Publication status	Published - 1986 Aug 6

Subject classification (UKÄ)

Neurosciences

Free keywords

dorsal horn
glutamate
nociceptive primary afferent fibre
pain

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10.1016/0006-8993(86)90798-5

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abstract = "An antagonist to amino acid evoked excitation, γ-d-glutamylglycine (γ-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive afferent C-fibres. These results might be useful for development of centrally acting analgesic drugs.",

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First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist

Abstract

Subject classification (UKÄ)

Free keywords

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