Abstract
Protein MIG, from Streptococcus dysgalactiae, binds alpha2-macroglobulin and immunoglobulin G (IgG). MIG-derived fusion proteins with one to five IgG-binding repeats differed up to 72,000- fold in avidity for goat IgG, indicating a considerable cooperativity of the repeats. Significant sequence variation in the IgG-binding repeats was recognized. Protein MIG interacted with goat IgG1 via both the Fc and Fab parts.
Original language | English |
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Pages (from-to) | 413-416 |
Journal | Infection and Immunity |
Volume | 67 |
Issue number | 1 |
Publication status | Published - 1999 |
Subject classification (UKÄ)
- Infectious Medicine