Five homologous repeats of the protein G-related protein MIG cooperate in binding to goat immunoglobulin G

J Vasi, J Svensson, Inga-Maria Frick, H P Muller

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Protein MIG, from Streptococcus dysgalactiae, binds alpha2-macroglobulin and immunoglobulin G (IgG). MIG-derived fusion proteins with one to five IgG-binding repeats differed up to 72,000- fold in avidity for goat IgG, indicating a considerable cooperativity of the repeats. Significant sequence variation in the IgG-binding repeats was recognized. Protein MIG interacted with goat IgG1 via both the Fc and Fab parts.
Original languageEnglish
Pages (from-to)413-416
JournalInfection and Immunity
Volume67
Issue number1
Publication statusPublished - 1999

Subject classification (UKÄ)

  • Infectious Medicine

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