Flat and depressed colorectal tumours in a southern Swedish population: a prospective chromoendoscopic and histopathological study.0

S Tsuda, Bela Veress, E Tóth, Thomas Fork

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Abstract

Background: Flat and depressed colorectal tumours are common in Japan but are very rare or non-existent in Western countries.

Aims: To study the occurrence of flat colorectal tumours in a southern Swedish population.

Methods: In this prospective study, 371 consecutive European patients were examined by high resolution video colonoscopy combined with chromoendoscopy. The nature of the lesions was determined by histopathological examination.

Results: A total of 973 tumours were found; 907 (93.2%) were protruding and 66 (6.8%) were flat or depressed. Of the flat/depressed tumours, five (7.7%) were early adenocarcinomas infiltrating the submucosa. Eleven carcinomas (1.2%) were found among protruding tumours. High grade dysplasia was observed in 18% (n=11) of flat/depressed adenomas in contrast with 7.3% (n=65) of protruding adenomas, and occurred in smaller flat/depressed tumours compared with protruding ones (mean diameter 8 mm v 23 mm, respectively). Furthermore, high grade dysplasia was significantly more common in flat elevated tumours with central depression or in depressed adenomas (35.7%; 5/14) than in flat elevated adenomas (12.8%; 6/47).

Conclusion: Flat and depressed tumours exist in a Western population. Future studies should address whether or not chromoendoscopy with video colonoscopy is necessary in the search for flat colorectal neoplasms.
Original languageEnglish
Pages (from-to)550-555
JournalGut
Volume51
Issue number4
DOIs
Publication statusPublished - 2002

Subject classification (UKÄ)

  • Gastroenterology and Hepatology

Free keywords

  • Prospective Studies
  • Middle Age
  • Male
  • Human
  • Sweden: epidemiology
  • Support
  • Non-U.S. Gov't
  • Endoscopy
  • Adenoma: epidemiology
  • Adenoma: pathology
  • Adult
  • Aged
  • Colorectal Neoplasms: pathology
  • Carcinoma: pathology
  • Colorectal Neoplasms: epidemiology
  • Gastrointestinal: methods
  • Female
  • 80 and over
  • Carcinoma: epidemiology

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