Flow field-flow fractionation: Critical overview.

Research output: Contribution to journalReview articlepeer-review


This overview regards some critical issues in performing flow field-flow fractionation (flow FFF, FlFFF, AF4, HF-FlFFF, HF5). It includes the channel thickness, void time, channel-flow parabolic profile, channel-flow velocity gradient, uniformity of the cross-flow, sample injection time, relaxation/focusing time, width of sample starting zone, retention level, theoretical and experimental zone broadening, hydrodynamic threshold immobilisation/re-mobilisation, sample loss and adsorption, membrane fouling, sample mass overloading, problems with symmetrical channels, non-spherical sample particles, and method development. Good method development practice (GMDP) and good fractogram practice (GFP) is suggested.
Original languageEnglish
Pages (from-to)97-112
JournalJournal of Chromatography A
Publication statusPublished - 2013

Subject classification (UKÄ)

  • Chemical Sciences


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