TY - JOUR
T1 - Fracture Risk Assessment in Older Adults Using a Combination of Selected Quantitative Computed Tomography Bone Measures: A Subanalysis of the Age, Gene/Environment Susceptibility-Reykjavik Study
AU - Rianon, Nahid J.
AU - Lang, Thomas F.
AU - Siggeirsdottir, Kristin
AU - Sigurdsson, Gunnar
AU - Eiriksdottir, Gudny
AU - Sigurdsson, Sigurdur
AU - Jonsson, Brynjolfur
AU - Garcia, Melissa
AU - Yu, Binbing
AU - Kapadia, Asha S.
AU - Taylor, Wendell C.
AU - Selwyn, Beatrice J.
AU - Gudnason, Vilmundur
AU - Launer, Lenore J.
AU - Harris, Tamara B.
PY - 2014
Y1 - 2014
N2 - Bone mineral density (BMD) and geometric bone measures are individually associated with prevalent osteoporotic fractures. Whether an aggregate of these measures would better associate with fractures has not been examined. We examined relationships between self-reported fractures and selected bone measures acquired by quantitative computerized tomography (QCT), a composite bone score, and QCT-acquired dual-energy X-ray absorptiometry-like total femur BMD in 2110 men and 2682 women in the Age, Gene/Environment Susceptibility-Reykjavik Study. The combined bone score was generated by summing gender-specific Z-scores for 4 QCT measures: vertebral trabecular BMD, femur neck cortical thickness, femur neck trabecular BMD, and femur neck minimal cross-sectional area. Except for the latter measure, lower scores for QCT measures, singly and combined, showed positive (p < 0.05) associations with fractures. Results remained the same in stratified models for participants not taking bone-promoting medication. In women on bone-promoting medication, greater femur neck cortical thickness and trabecular BMD were significantly associated with fracture status. However, the association between fracture and combined bone score was not stronger than the associations between fracture and individual measures or total femur BMD. Thus, the selected measures did not all similarly associate with fracture status and did not appear to have an additive effect on fracture status.
AB - Bone mineral density (BMD) and geometric bone measures are individually associated with prevalent osteoporotic fractures. Whether an aggregate of these measures would better associate with fractures has not been examined. We examined relationships between self-reported fractures and selected bone measures acquired by quantitative computerized tomography (QCT), a composite bone score, and QCT-acquired dual-energy X-ray absorptiometry-like total femur BMD in 2110 men and 2682 women in the Age, Gene/Environment Susceptibility-Reykjavik Study. The combined bone score was generated by summing gender-specific Z-scores for 4 QCT measures: vertebral trabecular BMD, femur neck cortical thickness, femur neck trabecular BMD, and femur neck minimal cross-sectional area. Except for the latter measure, lower scores for QCT measures, singly and combined, showed positive (p < 0.05) associations with fractures. Results remained the same in stratified models for participants not taking bone-promoting medication. In women on bone-promoting medication, greater femur neck cortical thickness and trabecular BMD were significantly associated with fracture status. However, the association between fracture and combined bone score was not stronger than the associations between fracture and individual measures or total femur BMD. Thus, the selected measures did not all similarly associate with fracture status and did not appear to have an additive effect on fracture status.
KW - Bone mineral density
KW - bone strength
KW - elderly
KW - fracture
KW - quantitative
KW - computerized tomography
U2 - 10.1016/j.jocd.2013.03.005
DO - 10.1016/j.jocd.2013.03.005
M3 - Article
C2 - 23562129
SN - 1094-6950
VL - 17
SP - 25
EP - 31
JO - Journal of Clinical Densitometry
JF - Journal of Clinical Densitometry
IS - 1
ER -