Functional connectivity in behavioral variant frontotemporal dementia

Luiz Kobuti Ferreira, Olof Lindberg, Alexander F. Santillo, Lars Olof Wahlund

Research output: Contribution to journalReview articlepeer-review


Introduction: Functional connectivity (FC)—which reflects relationships between neural activity in different brain regions—has been used to explore the functional architecture of the brain in neurodegenerative disorders. Although an increasing number of studies have explored FC changes in behavioral variant frontotemporal dementia (bvFTD), there is no focused, in-depth review about FC in bvFTD. Methods: Comprehensive literature search and narrative review to summarize the current field of FC in bvFTD. Results: (1) Decreased FC within the salience network (SN) is the most consistent finding in bvFTD; (2) FC changes extend beyond the SN and affect the interplay between networks; (3) results within the Default Mode Network are mixed; (4) the brain as a network is less interconnected and less efficient in bvFTD; (5) symptoms, functional impairment, and cognition are associated with FC; and (6) the functional architecture resembles patterns of neuropathological spread. Conclusions: FC has potential as a biomarker, and future studies are expected to advance the field with multicentric initiatives, longitudinal designs, and methodological advances.

Original languageEnglish
Article numbere2790
JournalBrain and Behavior
Issue number12
Early online date2022
Publication statusPublished - 2022 Dec

Bibliographical note

Funding Information:
Alexander F. Santillo has been supported by funds from Lund University, Region Skåne and The Schörling Foundation.

Publisher Copyright:
© 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC.

Subject classification (UKÄ)

  • Neurology

Free keywords

  • brain
  • bvFTD
  • fMRI
  • frontotemporal dementia
  • functional connectivity


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