Furanocoumarins with affinity to brain benzodiazepine receptors in vitro

Ola Bergendorff, Kim Dekermendjian, Mogens Nielsen, Rudong Shan, Robin Witt, Jinglu Ai, Olov Sterner

Research output: Contribution to journalArticlepeer-review


Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.
Original languageEnglish
Pages (from-to)1121-1124
Issue number6
Publication statusPublished - 1997

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Department of Dermatology and Venereology (Lund) (013006000), Organic chemistry (S/LTH) (011001240)

Subject classification (UKÄ)

  • Dermatology and Venereal Diseases


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