Furanocoumarins with affinity to brain benzodiazepine receptors in vitro

Ola Bergendorff; Kim Dekermendjian; Mogens Nielsen; Rudong Shan; Robin Witt; Jinglu Ai; Olov Sterner

doi:10.1016/S0031-9422(96)00703-0

Furanocoumarins with affinity to brain benzodiazepine receptors in vitro

Ola Bergendorff, Kim Dekermendjian, Mogens Nielsen, Rudong Shan, Robin Witt, Jinglu Ai, Olov Sterner

Research output: Contribution to journal › Article › peer-review

Abstract

Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.

Original language	English
Pages (from-to)	1121-1124
Journal	Phytochemistry
Volume	44
Issue number	6
DOIs	https://doi.org/10.1016/S0031-9422(96)00703-0
Publication status	Published - 1997

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Department of Dermatology and Venereology (Lund) (013006000), Organic chemistry (S/LTH) (011001240)

Subject classification (UKÄ)

Dermatology and Venereal Diseases

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10.1016/S0031-9422(96)00703-0

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title = "Furanocoumarins with affinity to brain benzodiazepine receptors in vitro",

abstract = "Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.",

author = "Ola Bergendorff and Kim Dekermendjian and Mogens Nielsen and Rudong Shan and Robin Witt and Jinglu Ai and Olov Sterner",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Dermatology and Venereology (Lund) (013006000), Organic chemistry (S/LTH) (011001240)",

year = "1997",

doi = "10.1016/S0031-9422(96)00703-0",

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T1 - Furanocoumarins with affinity to brain benzodiazepine receptors in vitro

AU - Bergendorff, Ola

AU - Dekermendjian, Kim

AU - Nielsen, Mogens

AU - Shan, Rudong

AU - Witt, Robin

AU - Ai, Jinglu

AU - Sterner, Olov

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Dermatology and Venereology (Lund) (013006000), Organic chemistry (S/LTH) (011001240)

PY - 1997

Y1 - 1997

N2 - Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.

AB - Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.

U2 - 10.1016/S0031-9422(96)00703-0

DO - 10.1016/S0031-9422(96)00703-0

M3 - Article

SN - 0031-9422

VL - 44

SP - 1121

EP - 1124

JO - Phytochemistry

JF - Phytochemistry

IS - 6

ER -

Furanocoumarins with affinity to brain benzodiazepine receptors in vitro

Abstract

Bibliographical note

Subject classification (UKÄ)

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