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Abstract
Background and Aims:
Although endovascular stent treatment is increasingly used in infrain-guinal atherosclerotic occlusive disease, outcome with focus on gender differences has not been reported in detail.
Material and Methods:
One hundred and twelve consecutive patients (67 [60%]) women, un-dergoing endovascular nitinol stent treatment of atherosclerotic lesions in the femoropopliteal segment were analysed concerning improvement in ankle brachial index (ABI), reinterventions, complications, amputation and survival rates up to 12 months after intervention. Risk factors for amputation and death were analyzed with logistic regression.
Results: At presentation, women showed critical limb ischemia (CLI) more often than men (87% vs. 58 %; P = 0.001). After 12 months ABI had improved (from 0.40 ± 0.26 at baseline to 0.86 ± 0.22 after 12 months, P < 0.001), but 16 patients (15%) had been amputated and 27 patients (24 %) had died. After adjustment for age, diabetes mellitus and smoking, female gender was an independent risk factor for amputation (OR 9.0; 95% CI 1.1-76.5; P = 0.045).
Conclusions: Stent treatment of lesions in the femoropopliteal segment had favourable effects on ABI and limb salvage. Treated women more often had CLI and ran a higher risk for amputation within 12 months than men. This might reflect failure of clinicians to adequately appreciate symptoms of atherosclerotic leg artery disease in women.
Although endovascular stent treatment is increasingly used in infrain-guinal atherosclerotic occlusive disease, outcome with focus on gender differences has not been reported in detail.
Material and Methods:
One hundred and twelve consecutive patients (67 [60%]) women, un-dergoing endovascular nitinol stent treatment of atherosclerotic lesions in the femoropopliteal segment were analysed concerning improvement in ankle brachial index (ABI), reinterventions, complications, amputation and survival rates up to 12 months after intervention. Risk factors for amputation and death were analyzed with logistic regression.
Results: At presentation, women showed critical limb ischemia (CLI) more often than men (87% vs. 58 %; P = 0.001). After 12 months ABI had improved (from 0.40 ± 0.26 at baseline to 0.86 ± 0.22 after 12 months, P < 0.001), but 16 patients (15%) had been amputated and 27 patients (24 %) had died. After adjustment for age, diabetes mellitus and smoking, female gender was an independent risk factor for amputation (OR 9.0; 95% CI 1.1-76.5; P = 0.045).
Conclusions: Stent treatment of lesions in the femoropopliteal segment had favourable effects on ABI and limb salvage. Treated women more often had CLI and ran a higher risk for amputation within 12 months than men. This might reflect failure of clinicians to adequately appreciate symptoms of atherosclerotic leg artery disease in women.
| Original language | English |
|---|---|
| Pages (from-to) | 177-183 |
| Journal | Scandinavian Journal of Surgery |
| Volume | 101 |
| Issue number | 3 |
| Publication status | Published - 2012 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Department of Rheumatology (013036000), Division of Nursing (Closed 2012) (013065000), Unit for Clinical Vascular Disease Research (013242410)
Subject classification (UKÄ)
- Surgery
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- 1 Doctoral Thesis (compilation)
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Peripheral Arterial Disease with focus on Intermittent Claudication. Outcome after Invasive Treatment
LINDGREN, H., 2016, Lund: Lund University: Faculty of Medicine. 102 p.Research output: Thesis › Doctoral Thesis (compilation)
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