Gene expression signature of acquired chemoresistance in neuroblastoma cells

Mohamed Jemaà, Wondossen Sime, Yasmin Abassi, Vito Alessandro Lasorsa, Julie Bonne Køhler, Martin Michaelis, Jindrich Cinatl, Mario Capasso, Ramin Massoumi

Research output: Contribution to journalArticlepeer-review


Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. Patients with relapsed disease have a poor prognosis despite intense treatment. In the present study, we aimed to identify chemoresistance gene expression signatures in vincristine resistant neuroblastoma cells. We found that vincristine-resistant neuroblastoma cells formed larger clones and survived under reduced serum conditions as compared with non-resistant parental cells. To identify the possible mechanisms underlying vincristine resistance in neuroblastoma cells, we investigated the expression profiles of genes known to be involved in cancer drug resistance. This specific gene expression patterns could predict the behavior of a tumor in response to chemotherapy and for predicting the prognosis of high-risk neuroblastoma patients. Our signature could help chemoresistant neuroblastoma patients in avoiding useless and harmful chemotherapy cycles.

Original languageEnglish
Article number6811
Number of pages15
JournalInternational Journal of Molecular Sciences
Issue number18
Publication statusPublished - 2020

Subject classification (UKÄ)

  • Cancer and Oncology

Free keywords

  • Chemoresistance
  • Neuroblastoma
  • Vincristine


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