Generation of an integration-free induced pluripotent stem cell line (CSC-43J) from a patient with sporadic Parkinson's disease

Ana Marote, Yuriy Pomeshchik, Stefano Goldwurm, Anna Collin, Nuno J. Lamas, Luísa Pinto, António J. Salgado, Laurent Roybon

Research output: Contribution to journalArticlepeer-review

2 Citations (SciVal)

Abstract

An induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated cell line (CSC-43) exhibits expression of common pluripotency markers, in vitro differentiation into three germ layers and normal karyotype. This iPSC line can be used to study the mechanisms underlying the development of PD.

Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalStem Cell Research
Volume27
DOIs
Publication statusPublished - 2018 Mar 1

Subject classification (UKÄ)

  • Neurosciences

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