Genetic mouse models to investigate cell cycle regulation

Weimin Li, Shuhei Kotoshiba, Philipp Kaldis

Research output: Contribution to journalReview articlepeer-review

Abstract

Early studies on cell cycle regulation were based on experiments in model systems (Yeast, Xenopus, Starfish, Drosophila) and have shaped the way we understand many events that control the cell cycle. Although these model systems are of great value, the last decade was highlighted by studies done in human cells and using in vivo mouse models. Mouse models are irreplaceable tools for understanding the genetics, development, and survival strategies of mammals. New developments in generating targeting vectors and mutant mice have improved our approaches to study cell cycle regulation and cancer. Here we summarize the most recent advances of mouse model approaches in dissecting the mechanisms of cell cycle regulation and the relevance to human disease.

Original languageEnglish
Pages (from-to)491-498
JournalTransgenic Research
Volume18
Issue number4
DOIs
Publication statusPublished - 2009 Jun 1
Externally publishedYes

Free keywords

  • Cell cycle regulation
  • Cre recombinase
  • ES cells
  • Frt recombinase
  • Genetic mouse models
  • Homologous recombination

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