Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

Y Horikawa; N Oda; N J Cox; X Li; Marju Orho-Melander; M Hara; Y Hinokio; T H Lindner; H Mashima; P E Schwarz; L del Bosque-Plata; Y Horikawa; Y Oda; I Yoshiuchi; S Colilla; K S Polonsky; S Wei; P Concannon; N Iwasaki; J Schulze; Leslie J. Baier; Clifton Bogardus; Leif Groop; Eric Boerwinkle; Craig L. Hanis; Graeme I. Bell

doi:10.1038/79876

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

Y Horikawa, N Oda, N J Cox, X Li, Marju Orho-Melander, M Hara, Y Hinokio, T H Lindner, H Mashima, P E Schwarz, L del Bosque-Plata, Y Horikawa, Y Oda, I Yoshiuchi, S Colilla, K S Polonsky, S Wei, P Concannon, N Iwasaki, J SchulzeLeslie J. Baier, Clifton Bogardus, Leif Groop, Eric Boerwinkle, Craig L. Hanis, Graeme I. Bell

Translational Muscle Research

Research output: Contribution to journal › Article › peer-review

Abstract

Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.

Original language	English
Pages (from-to)	163-175
Journal	Nature Genetics
Volume	26
Issue number	2
DOIs	https://doi.org/10.1038/79876
Publication status	Published - 2000

Subject classification (UKÄ)

Endocrinology and Diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/79876

Cite this

Horikawa, Y., Oda, N., Cox, N. J., Li, X., Orho-Melander, M., Hara, M., Hinokio, Y., Lindner, T. H., Mashima, H., Schwarz, P. E., del Bosque-Plata, L., Horikawa, Y., Oda, Y., Yoshiuchi, I., Colilla, S., Polonsky, K. S., Wei, S., Concannon, P., Iwasaki, N., ... Bell, G. I. (2000). Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nature Genetics, 26(2), 163-175. https://doi.org/10.1038/79876

@article{ad4d5ab37a8c41d286b9c740b0fa2a81,

title = "Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus",

abstract = "Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.",

author = "Y Horikawa and N Oda and Cox, {N J} and X Li and Marju Orho-Melander and M Hara and Y Hinokio and Lindner, {T H} and H Mashima and Schwarz, {P E} and {del Bosque-Plata}, L and Y Horikawa and Y Oda and I Yoshiuchi and S Colilla and Polonsky, {K S} and S Wei and P Concannon and N Iwasaki and J Schulze and Baier, {Leslie J.} and Clifton Bogardus and Leif Groop and Eric Boerwinkle and Hanis, {Craig L.} and Bell, {Graeme I.}",

year = "2000",

doi = "10.1038/79876",

language = "English",

volume = "26",

pages = "163--175",

journal = "Nature Genetics",

issn = "1546-1718",

publisher = "Nature Publishing Group",

number = "2",

}

Horikawa, Y, Oda, N, Cox, NJ, Li, X, Orho-Melander, M, Hara, M, Hinokio, Y, Lindner, TH, Mashima, H, Schwarz, PE, del Bosque-Plata, L, Horikawa, Y, Oda, Y, Yoshiuchi, I, Colilla, S, Polonsky, KS, Wei, S, Concannon, P, Iwasaki, N, Schulze, J, Baier, LJ, Bogardus, C, Groop, L, Boerwinkle, E, Hanis, CL & Bell, GI 2000, 'Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus', Nature Genetics, vol. 26, no. 2, pp. 163-175. https://doi.org/10.1038/79876

TY - JOUR

T1 - Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

AU - Horikawa, Y

AU - Oda, N

AU - Cox, N J

AU - Li, X

AU - Orho-Melander, Marju

AU - Hara, M

AU - Hinokio, Y

AU - Lindner, T H

AU - Mashima, H

AU - Schwarz, P E

AU - del Bosque-Plata, L

AU - Horikawa, Y

AU - Oda, Y

AU - Yoshiuchi, I

AU - Colilla, S

AU - Polonsky, K S

AU - Wei, S

AU - Concannon, P

AU - Iwasaki, N

AU - Schulze, J

AU - Baier, Leslie J.

AU - Bogardus, Clifton

AU - Groop, Leif

AU - Boerwinkle, Eric

AU - Hanis, Craig L.

AU - Bell, Graeme I.

PY - 2000

Y1 - 2000

N2 - Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.

AB - Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.

U2 - 10.1038/79876

DO - 10.1038/79876

M3 - Article

C2 - 11017071

SN - 1546-1718

VL - 26

SP - 163

EP - 175

JO - Nature Genetics

JF - Nature Genetics

IS - 2

ER -

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

Abstract

Subject classification (UKÄ)

UN SDGs

Access to Document

Fingerprint

Cite this