Genetics- and Immune-Related Factors in the Pathogenesis of Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia

Sigurdur Y. Kristinsson; Jill Koshiol; Lynn R. Goldin; Magnus Bjorkholm; Ingemar Turesson; Gloria Gridley; Mary L. McMaster; Ola Landgren

doi:10.3816/CLM.2009.n.004

Genetics- and Immune-Related Factors in the Pathogenesis of Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia

Sigurdur Y. Kristinsson, Jill Koshiol, Lynn R. Goldin, Magnus Bjorkholm, Ingemar Turesson, Gloria Gridley, Mary L. McMaster, Ola Landgren

Department of Clinical Sciences, Malmö

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

Abstract

There are emerging data to support a role for genetic and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia. In this article, we review our recently published, large, population-based studies using data from Sweden and from United States veterans and propose mechanisms and pathways underlying our observations. We also discuss future directions for new studies designed to increase our current knowledge and to define underlying biologic mechanisms of our findings. Finally, based on novel insights on this topic, we discuss clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up.

Original language	English
Title of host publication	Clinical Lymphoma & Myeloma
Publisher	CIG Media Group
Pages	23-26
Volume	9
DOIs	https://doi.org/10.3816/CLM.2009.n.004
Publication status	Published - 2009
Event	5th International Workshop on Waldenstroms Macroglobulinemia - Stockholm, SWEDEN Duration: 2008 Oct 15 → 2008 Oct 19

Publication series

Name
Number	1
Volume	9
ISSN (Print)	1557-9190

Conference

Conference	5th International Workshop on Waldenstroms Macroglobulinemia
Period	2008/10/15 → 2008/10/19

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)

Subject classification (UKÄ)

Clinical Medicine

Free keywords

Susceptibility
Rheumatoid arthritis
Lymphoproliferative malignancy
Hepatitis C virus
Autoimmune disease
Familial aggregation

Access to Document

10.3816/CLM.2009.n.004

Cite this

@inproceedings{b3dbecb64f5441bc95e4bc6406677cad,

title = "Genetics- and Immune-Related Factors in the Pathogenesis of Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia",

abstract = "There are emerging data to support a role for genetic and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia. In this article, we review our recently published, large, population-based studies using data from Sweden and from United States veterans and propose mechanisms and pathways underlying our observations. We also discuss future directions for new studies designed to increase our current knowledge and to define underlying biologic mechanisms of our findings. Finally, based on novel insights on this topic, we discuss clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up.",

keywords = "Susceptibility, Rheumatoid arthritis, Lymphoproliferative malignancy, Hepatitis C virus, Autoimmune disease, Familial aggregation",

author = "Kristinsson, {Sigurdur Y.} and Jill Koshiol and Goldin, {Lynn R.} and Magnus Bjorkholm and Ingemar Turesson and Gloria Gridley and McMaster, {Mary L.} and Ola Landgren",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200); 5th International Workshop on Waldenstroms Macroglobulinemia ; Conference date: 15-10-2008 Through 19-10-2008",

year = "2009",

doi = "10.3816/CLM.2009.n.004",

language = "English",

volume = "9",

publisher = "CIG Media Group",

number = "1",

pages = "23--26",

booktitle = "Clinical Lymphoma & Myeloma",

}

Kristinsson, SY, Koshiol, J, Goldin, LR, Bjorkholm, M, Turesson, I, Gridley, G, McMaster, ML & Landgren, O 2009, Genetics- and Immune-Related Factors in the Pathogenesis of Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia. in Clinical Lymphoma & Myeloma. vol. 9, CIG Media Group, pp. 23-26, 5th International Workshop on Waldenstroms Macroglobulinemia, 2008/10/15. https://doi.org/10.3816/CLM.2009.n.004

TY - GEN

T1 - Genetics- and Immune-Related Factors in the Pathogenesis of Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia

AU - Kristinsson, Sigurdur Y.

AU - Koshiol, Jill

AU - Goldin, Lynn R.

AU - Bjorkholm, Magnus

AU - Turesson, Ingemar

AU - Gridley, Gloria

AU - McMaster, Mary L.

AU - Landgren, Ola

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)

PY - 2009

Y1 - 2009

N2 - There are emerging data to support a role for genetic and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia. In this article, we review our recently published, large, population-based studies using data from Sweden and from United States veterans and propose mechanisms and pathways underlying our observations. We also discuss future directions for new studies designed to increase our current knowledge and to define underlying biologic mechanisms of our findings. Finally, based on novel insights on this topic, we discuss clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up.

AB - There are emerging data to support a role for genetic and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia. In this article, we review our recently published, large, population-based studies using data from Sweden and from United States veterans and propose mechanisms and pathways underlying our observations. We also discuss future directions for new studies designed to increase our current knowledge and to define underlying biologic mechanisms of our findings. Finally, based on novel insights on this topic, we discuss clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up.

KW - Susceptibility

KW - Rheumatoid arthritis

KW - Lymphoproliferative malignancy

KW - Hepatitis C virus

KW - Autoimmune disease

KW - Familial aggregation

U2 - 10.3816/CLM.2009.n.004

DO - 10.3816/CLM.2009.n.004

M3 - Paper in conference proceeding

C2 - 19362964

VL - 9

SP - 23

EP - 26

BT - Clinical Lymphoma & Myeloma

PB - CIG Media Group

T2 - 5th International Workshop on Waldenstroms Macroglobulinemia

Y2 - 15 October 2008 through 19 October 2008

ER -

Genetics- and Immune-Related Factors in the Pathogenesis of Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia

Abstract

Publication series

Conference

Bibliographical note

Subject classification (UKÄ)

Free keywords

Access to Document

Fingerprint

Cite this