Genetics- and Immune-Related Factors in the Pathogenesis of Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia

Sigurdur Y. Kristinsson, Jill Koshiol, Lynn R. Goldin, Magnus Bjorkholm, Ingemar Turesson, Gloria Gridley, Mary L. McMaster, Ola Landgren

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review


There are emerging data to support a role for genetic and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia. In this article, we review our recently published, large, population-based studies using data from Sweden and from United States veterans and propose mechanisms and pathways underlying our observations. We also discuss future directions for new studies designed to increase our current knowledge and to define underlying biologic mechanisms of our findings. Finally, based on novel insights on this topic, we discuss clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up.
Original languageEnglish
Title of host publicationClinical Lymphoma & Myeloma
PublisherCIG Media Group
Publication statusPublished - 2009
Event5th International Workshop on Waldenstroms Macroglobulinemia - Stockholm, SWEDEN
Duration: 2008 Oct 152008 Oct 19

Publication series

ISSN (Print)1557-9190


Conference5th International Workshop on Waldenstroms Macroglobulinemia

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)

Subject classification (UKÄ)

  • Clinical Medicine

Free keywords

  • Susceptibility
  • Rheumatoid arthritis
  • Lymphoproliferative malignancy
  • Hepatitis C virus
  • Autoimmune disease
  • Familial aggregation


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