Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.

Elisabet Agardh; Annika Lundstig; Alexander Perfilyev; Petr Volkov; Tove Freiburghaus; Eero Lindholm; Tina Rönn; Carl-David Agardh; Charlotte Ling

doi:10.1186/s12916-015-0421-5

Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.

Elisabet Agardh, Annika Lundstig, Alexander Perfilyev, Petr Volkov, Tove Freiburghaus, Eero Lindholm, Tina Rönn, Carl-David Agardh, Charlotte Ling

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Abstract

Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with diabetes. However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D).

Original language	English
Journal	BMC Medicine
Volume	13
Issue number	182
DOIs	https://doi.org/10.1186/s12916-015-0421-5
Publication status	Published - 2015

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Diabetes and Celiac Unit (013241540), Diabetes and Endocrinology (013241530), Unit on Vascular Diabetic Complications (013241510), Faculty of Medicine (000022000), Epigenetics and Diabetes (013241505), Ophthalmology (013242810)

Subject classification (UKÄ)

Endocrinology and Diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12916-015-0421-5

bmc_Agardh

http://www.ncbi.nlm.nih.gov/pubmed/26248552?dopt=Abstract

Cite this

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title = "Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.",

abstract = "Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with diabetes. However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D).",

author = "Elisabet Agardh and Annika Lundstig and Alexander Perfilyev and Petr Volkov and Tove Freiburghaus and Eero Lindholm and Tina R{\"o}nn and Carl-David Agardh and Charlotte Ling",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diabetes and Celiac Unit (013241540), Diabetes and Endocrinology (013241530), Unit on Vascular Diabetic Complications (013241510), Faculty of Medicine (000022000), Epigenetics and Diabetes (013241505), Ophthalmology (013242810)",

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doi = "10.1186/s12916-015-0421-5",

language = "English",

volume = "13",

journal = "BMC Medicine",

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T1 - Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.

AU - Agardh, Elisabet

AU - Lundstig, Annika

AU - Perfilyev, Alexander

AU - Volkov, Petr

AU - Freiburghaus, Tove

AU - Lindholm, Eero

AU - Rönn, Tina

AU - Agardh, Carl-David

AU - Ling, Charlotte

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diabetes and Celiac Unit (013241540), Diabetes and Endocrinology (013241530), Unit on Vascular Diabetic Complications (013241510), Faculty of Medicine (000022000), Epigenetics and Diabetes (013241505), Ophthalmology (013242810)

PY - 2015

Y1 - 2015

N2 - Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with diabetes. However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D).

AB - Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with diabetes. However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D).

U2 - 10.1186/s12916-015-0421-5

DO - 10.1186/s12916-015-0421-5

M3 - Article

C2 - 26248552

SN - 1741-7015

VL - 13

JO - BMC Medicine

JF - BMC Medicine

IS - 182

ER -

Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.

Abstract

Bibliographical note

Subject classification (UKÄ)

UN SDGs

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