Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.

Elisabet Agardh, Annika Lundstig, Alexander Perfilyev, Petr Volkov, Tove Freiburghaus, Eero Lindholm, Tina Rönn, Carl-David Agardh, Charlotte Ling

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Abstract

Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with diabetes. However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D).
Original languageEnglish
JournalBMC Medicine
Volume13
Issue number182
DOIs
Publication statusPublished - 2015

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Diabetes and Celiac Unit (013241540), Diabetes and Endocrinology (013241530), Unit on Vascular Diabetic Complications (013241510), Faculty of Medicine (000022000), Epigenetics and Diabetes (013241505), Ophthalmology (013242810)

Subject classification (UKÄ)

  • Endocrinology and Diabetes

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