Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival

Weiqiang Li; Mridu Middha; Mesude Bicak; Daniel D. Sjoberg; Emily Vertosick; Anders Dahlin; Christel Häggström; Göran Hallmans; Ann Charlotte Rönn; Pär Stattin; Olle Melander; David Ulmert; Hans Lilja; Robert J. Klein

doi:10.1016/j.eururo.2018.06.021

Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival

Weiqiang Li, Mridu Middha, Mesude Bicak, Daniel D. Sjoberg, Emily Vertosick, Anders Dahlin, Christel Häggström, Göran Hallmans, Ann Charlotte Rönn, Pär Stattin, Olle Melander, David Ulmert, Hans Lilja, Robert J. Klein

Research output: Contribution to journal › Article › peer-review

Abstract

We performed genome-wide association studies and found single nucleotide polymorphisms (SNPs) at seven independent loci associated with prostate-cancer-specific survival time. Two SNPs replicated in an independent cohort. The SNP rs73055188 at AOX1 is associated with AOX1 gene expression level, which is correlated with biochemical recurrence.

Original language	English
Pages (from-to)	710-719
Journal	European Urology
Volume	74
Issue number	6
Early online date	2018 Jan 1
DOIs	https://doi.org/10.1016/j.eururo.2018.06.021
Publication status	Published - 2018

Subject classification (UKÄ)

Medical Genetics
Cancer and Oncology

Free keywords

AOX1
Expression quantitative trait locus
Genome-wide association study
Prostate cancer
Survival analysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.eururo.2018.06.021

Cite this

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title = "Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival",

abstract = "We performed genome-wide association studies and found single nucleotide polymorphisms (SNPs) at seven independent loci associated with prostate-cancer-specific survival time. Two SNPs replicated in an independent cohort. The SNP rs73055188 at AOX1 is associated with AOX1 gene expression level, which is correlated with biochemical recurrence.",

keywords = "AOX1, Expression quantitative trait locus, Genome-wide association study, Prostate cancer, Survival analysis",

author = "Weiqiang Li and Mridu Middha and Mesude Bicak and Sjoberg, {Daniel D.} and Emily Vertosick and Anders Dahlin and Christel H{\"a}ggstr{\"o}m and G{\"o}ran Hallmans and R{\"o}nn, {Ann Charlotte} and P{\"a}r Stattin and Olle Melander and David Ulmert and Hans Lilja and Klein, {Robert J.}",

year = "2018",

doi = "10.1016/j.eururo.2018.06.021",

language = "English",

volume = "74",

pages = "710--719",

journal = "European Urology",

issn = "0302-2838",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival

AU - Li, Weiqiang

AU - Middha, Mridu

AU - Bicak, Mesude

AU - Sjoberg, Daniel D.

AU - Vertosick, Emily

AU - Dahlin, Anders

AU - Häggström, Christel

AU - Hallmans, Göran

AU - Rönn, Ann Charlotte

AU - Stattin, Pär

AU - Melander, Olle

AU - Ulmert, David

AU - Lilja, Hans

AU - Klein, Robert J.

PY - 2018

Y1 - 2018

N2 - We performed genome-wide association studies and found single nucleotide polymorphisms (SNPs) at seven independent loci associated with prostate-cancer-specific survival time. Two SNPs replicated in an independent cohort. The SNP rs73055188 at AOX1 is associated with AOX1 gene expression level, which is correlated with biochemical recurrence.

AB - We performed genome-wide association studies and found single nucleotide polymorphisms (SNPs) at seven independent loci associated with prostate-cancer-specific survival time. Two SNPs replicated in an independent cohort. The SNP rs73055188 at AOX1 is associated with AOX1 gene expression level, which is correlated with biochemical recurrence.

KW - AOX1

KW - Expression quantitative trait locus

KW - Genome-wide association study

KW - Prostate cancer

KW - Survival analysis

UR - http://www.scopus.com/inward/record.url?scp=85049454744&partnerID=8YFLogxK

U2 - 10.1016/j.eururo.2018.06.021

DO - 10.1016/j.eururo.2018.06.021

M3 - Article

C2 - 30289108

AN - SCOPUS:85049454744

SN - 0302-2838

VL - 74

SP - 710

EP - 719

JO - European Urology

JF - European Urology

IS - 6

ER -

Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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