Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival

Weiqiang Li, Mridu Middha, Mesude Bicak, Daniel D. Sjoberg, Emily Vertosick, Anders Dahlin, Christel Häggström, Göran Hallmans, Ann Charlotte Rönn, Pär Stattin, Olle Melander, David Ulmert, Hans Lilja, Robert J. Klein

Research output: Contribution to journalArticlepeer-review


We performed genome-wide association studies and found single nucleotide polymorphisms (SNPs) at seven independent loci associated with prostate-cancer-specific survival time. Two SNPs replicated in an independent cohort. The SNP rs73055188 at AOX1 is associated with AOX1 gene expression level, which is correlated with biochemical recurrence.

Original languageEnglish
Pages (from-to)710-719
JournalEuropean Urology
Issue number6
Early online date2018 Jan 1
Publication statusPublished - 2018

Subject classification (UKÄ)

  • Medical Genetics
  • Cancer and Oncology

Free keywords

  • AOX1
  • Expression quantitative trait locus
  • Genome-wide association study
  • Prostate cancer
  • Survival analysis


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