Genomic organization of the leukotriene B(4) receptor locus of human chromosome 14

Niclas Nilsson, Ylva Tryselius, Christer Owman

Research output: Contribution to journalArticlepeer-review

Abstract

The genomic region containing the genes encoding the first leukotriene B(4) receptor, BLTR, as well as the recently cloned second leukotriene B(4)-activated receptor, BLTR2, was mapped by (a) sequence analysis of a human bacterial artificial chromosome (BAC) library containing a 15-kb segment corresponding to chromosome 14q11. 2-12 where the BLTR/BLTR2 genes were previously shown to be located, together with (b) sequence analysis of 83 expressed sequence tags (ESTs) from this region. The BLTR gene includes four different 5' untranslated regions (UTRs) and a mutual acceptor site for the exon containing the intronless open reading frame. The BLTR2 gene is intronless and overlapped by a 5' UTR splice version of BLTR and, on the reverse strand, of the apoptosis-related CIDE-B gene. This indicates a complex posttranscriptional gene regulation. Further adding to the complexity of the region is evidence of a fourth putative and novel gene, most homologous to the rat adenylyl cyclase IV gene.
Original languageEnglish
Pages (from-to)383-388
JournalBiochemical and Biophysical Research Communications
Volume274
Issue number2
DOIs
Publication statusPublished - 2000

Subject classification (UKÄ)

  • Biological Sciences

Fingerprint

Dive into the research topics of 'Genomic organization of the leukotriene B(4) receptor locus of human chromosome 14'. Together they form a unique fingerprint.

Cite this