GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma

S. Kuphal; G. Shaw-Hallgren; M. Eberl; S. Karrer; F. Aberger; A. K. Bosserhoff; Ramin Massoumi

doi:10.1038/onc.2011.163

GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma

S. Kuphal, G. Shaw-Hallgren, M. Eberl, S. Karrer, F. Aberger, A. K. Bosserhoff, Ramin Massoumi

Department of Translational Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

CYLD is a deubiquitination enzyme that regulates different cellular processes, such as cell proliferation and cell survival. Mutation and loss of heterozygosity of the CYLD gene causes development of cylindromatosis, a benign tumour originating from the skin. Our study shows that CYLD expression is dramatically downregulated in basal cell carcinoma (BCC), the most common cancer in humans. Reduced CYLD expression in basal cell carcinoma was mediated by GLI1-dependent activation of the transcriptional repressor Snail. Inhibition of GLI1 restored the CYLD expression-mediated Snail signaling pathway, and caused a significant delay in the G1 to S phase transition, as well as proliferation. Our data suggest that GLI1-mediated suppression of CYLD has a significant role in basal cell carcinoma progression. Oncogene (2011) 30, 4523-4530; doi: 10.1038/onc.2011.163; published online 16 May 2011

Original language	English
Pages (from-to)	4523-4530
Journal	Oncogene
Volume	30
Issue number	44
DOIs	https://doi.org/10.1038/onc.2011.163
Publication status	Published - 2011

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

CYLD
GLI1
Snail1
BCC
Bcl-3

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/onc.2011.163

Cite this

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title = "GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma",

abstract = "CYLD is a deubiquitination enzyme that regulates different cellular processes, such as cell proliferation and cell survival. Mutation and loss of heterozygosity of the CYLD gene causes development of cylindromatosis, a benign tumour originating from the skin. Our study shows that CYLD expression is dramatically downregulated in basal cell carcinoma (BCC), the most common cancer in humans. Reduced CYLD expression in basal cell carcinoma was mediated by GLI1-dependent activation of the transcriptional repressor Snail. Inhibition of GLI1 restored the CYLD expression-mediated Snail signaling pathway, and caused a significant delay in the G1 to S phase transition, as well as proliferation. Our data suggest that GLI1-mediated suppression of CYLD has a significant role in basal cell carcinoma progression. Oncogene (2011) 30, 4523-4530; doi: 10.1038/onc.2011.163; published online 16 May 2011",

keywords = "CYLD, GLI1, Snail1, BCC, Bcl-3",

author = "S. Kuphal and G. Shaw-Hallgren and M. Eberl and S. Karrer and F. Aberger and Bosserhoff, {A. K.} and Ramin Massoumi",

year = "2011",

doi = "10.1038/onc.2011.163",

language = "English",

volume = "30",

pages = "4523--4530",

journal = "Oncogene",

issn = "1476-5594",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma

AU - Kuphal, S.

AU - Shaw-Hallgren, G.

AU - Eberl, M.

AU - Karrer, S.

AU - Aberger, F.

AU - Bosserhoff, A. K.

AU - Massoumi, Ramin

PY - 2011

Y1 - 2011

N2 - CYLD is a deubiquitination enzyme that regulates different cellular processes, such as cell proliferation and cell survival. Mutation and loss of heterozygosity of the CYLD gene causes development of cylindromatosis, a benign tumour originating from the skin. Our study shows that CYLD expression is dramatically downregulated in basal cell carcinoma (BCC), the most common cancer in humans. Reduced CYLD expression in basal cell carcinoma was mediated by GLI1-dependent activation of the transcriptional repressor Snail. Inhibition of GLI1 restored the CYLD expression-mediated Snail signaling pathway, and caused a significant delay in the G1 to S phase transition, as well as proliferation. Our data suggest that GLI1-mediated suppression of CYLD has a significant role in basal cell carcinoma progression. Oncogene (2011) 30, 4523-4530; doi: 10.1038/onc.2011.163; published online 16 May 2011

AB - CYLD is a deubiquitination enzyme that regulates different cellular processes, such as cell proliferation and cell survival. Mutation and loss of heterozygosity of the CYLD gene causes development of cylindromatosis, a benign tumour originating from the skin. Our study shows that CYLD expression is dramatically downregulated in basal cell carcinoma (BCC), the most common cancer in humans. Reduced CYLD expression in basal cell carcinoma was mediated by GLI1-dependent activation of the transcriptional repressor Snail. Inhibition of GLI1 restored the CYLD expression-mediated Snail signaling pathway, and caused a significant delay in the G1 to S phase transition, as well as proliferation. Our data suggest that GLI1-mediated suppression of CYLD has a significant role in basal cell carcinoma progression. Oncogene (2011) 30, 4523-4530; doi: 10.1038/onc.2011.163; published online 16 May 2011

KW - CYLD

KW - GLI1

KW - Snail1

KW - BCC

KW - Bcl-3

U2 - 10.1038/onc.2011.163

DO - 10.1038/onc.2011.163

M3 - Article

C2 - 21577203

SN - 1476-5594

VL - 30

SP - 4523

EP - 4530

JO - Oncogene

JF - Oncogene

IS - 44

ER -

GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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