Glucose Detection With a Commercial MOSFET Using a ZnO Nanowires Extended Gate

Syed Muhammad Usman Ali, Omer Nur, Magnus Willander, Bengt Danielsson

Research output: Contribution to journalArticlepeer-review

57 Citations (SciVal)

Abstract

ZnO nanowires were grown on Ag wire with a diameter of similar to 250 mu m and used in an electrochemical sensor. The enzyme glucose oxidase (GOD) was immobilized on the ZnO nanowires, and the Ag wire was connected directly to the gate of a MOSFET. Upon exposure to glucose (1-100 mu M), the electrochemical response from the GOD induced a stable measurable voltage change on the gate leading to a strong modulation of the current through the MOSFET. For a sensor with uniform ZnO nanowires functionalized with GOD, a fast response time of less than 100 ms was demonstrated. The effect of the uniformity of the ZnO nanowires on the sensing property was also investigated. The extended-gate arrangement facilitated glucose detection in small sample volumes, and made it possible to demonstrate the present sensor concept using a standard low-threshold MOSFET. The extended-gate MOSFET sensor approach demonstrates the possibility and potential of the use of nanostructures coupled to standard electronic components for biosensing applications.
Original languageEnglish
Pages (from-to)678-683
JournalIEEE Transactions on Nanotechnology
Volume8
Issue number6
DOIs
Publication statusPublished - 2009

Subject classification (UKÄ)

  • Biochemistry and Molecular Biology

Keywords

  • MOSFETs
  • electrochemical devices
  • Biomedical transducers
  • biosensor

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