Abstract
AIMS: To investigate the association between glycemic control and outcome in people with type 2 diabetes (T2D) after carotid intervention due to carotid stenosis.
METHODS: Observational nationwide population-based cohort study using inverse probability treatment weighting (IPTW) and Cox regressions with covariates, that is, 4 stepwise models, investigating the relationship between terciles of glycated hemoglobin (HbA1c) levels and stroke or death.
RESULTS: 1115 subjects with T2D undergoing carotid intervention were included during Jan 1st 2009 to Dec 31st 2015. Divided into terciles, with a mean HbA1c level of 44 (tercile 1), 53 (tercile 2), and 72 (tercile 3) mmol/mol. By using IPTW and Cox regression, each model was stepwise introduced for the investigating of relative risks, that is, hazard ratios (HRs) with associated 95% confidence intervals (CI). There was a significant increased risk for stroke or death, in every model observed for tercile 3, compared to tercile 1: HR for model 4: 1.35 (95% CI 1.02-1.78). No difference for stroke or death within 30 days was observed between the groups.
CONCLUSION: Poor glycemic control in people with T2D after carotid intervention is associated with an increased long-term risk for stroke or death.
| Original language | English |
|---|---|
| Journal | Diabetes & Vascular Disease Research |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2023 |
Subject classification (UKÄ)
- Endocrinology and Diabetes
- Cardiology and Cardiovascular Disease
Free keywords
- Humans
- Cohort Studies
- Endarterectomy, Carotid/adverse effects
- Diabetes Mellitus, Type 2/complications
- Glycated Hemoglobin
- Glycemic Control/adverse effects
- Sweden/epidemiology
- Treatment Outcome
- Carotid Stenosis/diagnostic imaging
- Stroke/diagnosis
- Risk Factors
