GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization.

Martin Rehn; Peter-Martin Krarup; Lise H Christensen; Jakob B Seidelin; Magnus S Ågren; Ingvar Syk

doi:10.1089/sur.2014.248

GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization.

Martin Rehn, Peter-Martin Krarup, Lise H Christensen, Jakob B Seidelin, Magnus S Ågren, Ingvar Syk

Surgery

Research output: Contribution to journal › Article › peer-review

Abstract

Emergency operations performed on an obstructed colon are accompanied by an increased risk of anastomotic insufficiency. Tissue-destructive matrix metalloproteinase (MMP) activity is elevated in the obstructed colon and contributes to a loss of suture-holding submucosal collagen, which may be mediated by tumor necrosis factor (TNF)-α. Our aim was to study the effect of the non-selective MMP and TNF-α converting enzyme (TACE) inhibitor GM6001 (30 mg/kg) on anastomosis repair in obstructed left colon. GM6001 has been proved to be highly efficacious in elective anastomosis rodent models.

Original language	English
Pages (from-to)	702-708
Journal	Surgical Infections
Volume	16
Issue number	6
DOIs	https://doi.org/10.1089/sur.2014.248
Publication status	Published - 2015

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Surgery

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10.1089/sur.2014.248

http://www.ncbi.nlm.nih.gov/pubmed/26171681?dopt=Abstract

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title = "GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization.",

abstract = "Emergency operations performed on an obstructed colon are accompanied by an increased risk of anastomotic insufficiency. Tissue-destructive matrix metalloproteinase (MMP) activity is elevated in the obstructed colon and contributes to a loss of suture-holding submucosal collagen, which may be mediated by tumor necrosis factor (TNF)-α. Our aim was to study the effect of the non-selective MMP and TNF-α converting enzyme (TACE) inhibitor GM6001 (30 mg/kg) on anastomosis repair in obstructed left colon. GM6001 has been proved to be highly efficacious in elective anastomosis rodent models.",

author = "Martin Rehn and Peter-Martin Krarup and Christensen, \{Lise H\} and Seidelin, \{Jakob B\} and {\AA}gren, \{Magnus S\} and Ingvar Syk",

year = "2015",

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AU - Rehn, Martin

AU - Krarup, Peter-Martin

AU - Christensen, Lise H

AU - Seidelin, Jakob B

AU - Ågren, Magnus S

AU - Syk, Ingvar

PY - 2015

Y1 - 2015

N2 - Emergency operations performed on an obstructed colon are accompanied by an increased risk of anastomotic insufficiency. Tissue-destructive matrix metalloproteinase (MMP) activity is elevated in the obstructed colon and contributes to a loss of suture-holding submucosal collagen, which may be mediated by tumor necrosis factor (TNF)-α. Our aim was to study the effect of the non-selective MMP and TNF-α converting enzyme (TACE) inhibitor GM6001 (30 mg/kg) on anastomosis repair in obstructed left colon. GM6001 has been proved to be highly efficacious in elective anastomosis rodent models.

AB - Emergency operations performed on an obstructed colon are accompanied by an increased risk of anastomotic insufficiency. Tissue-destructive matrix metalloproteinase (MMP) activity is elevated in the obstructed colon and contributes to a loss of suture-holding submucosal collagen, which may be mediated by tumor necrosis factor (TNF)-α. Our aim was to study the effect of the non-selective MMP and TNF-α converting enzyme (TACE) inhibitor GM6001 (30 mg/kg) on anastomosis repair in obstructed left colon. GM6001 has been proved to be highly efficacious in elective anastomosis rodent models.

UR - https://www.scopus.com/pages/publications/84948694543

U2 - 10.1089/sur.2014.248

DO - 10.1089/sur.2014.248

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JO - Surgical Infections

JF - Surgical Infections

IS - 6

ER -

GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization.

Abstract

Subject classification (UKÄ)

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