Going to extremes - a metagenomic journey into the dark matter of life

Arnthór Aevarsson; Anna-Karina Kaczorowska; Björn Thor Adalsteinsson; Josefin Ahlqvist; Salam Al-Karadaghi; Joseph Altenbuchner; Hasan Arsin; Úlfur Áugúst Átlasson; David Brandt; Magdalena Cichowicz-Cieślak; Katy A S Cornish; Jérémy Courtin; Slawomir Dabrowski; Håkon Dahle; Samia Djeffane; Sebastian Dorawa; Julia Dusaucy; Francois Enault; Anita-Elin Fedøy; Stefanie Freitag-Pohl; Olafur H Fridjonsson; Clovis Galiez; Eirin Glomsaker; Mickael Guérin; Sigurd E Gundesø; Elisabet E Gudmundsdóttir; Hördur Gudmundsson; Maria Håkansson; Christian Henke; Alexandra Helleux; Jørn Remi Henriksen; Sigrídur Hjörleifdóttir; Gudmundur O Hreggvidsson; Andrius Jasilionis; Annika Jochheim; Ilmur Jónsdóttir; Lilja Björk Jónsdóttir; Agata Jurczak-Kurek; Tadeusz Kaczorowski; Jörn Kalinowski; Lukasz P Kozlowski; Mart Krupovic; Karolina Kwiatkowska-Semrau; Olav Lanes; Javier Linares-Pastén; Eva Nordberg Karlsson; Sigurlaug Skírnisdóttir; Anders Svensson; Björn Walse; Martin Welin; Ruoshi  Zhang; Virus-X

doi:10.1093/femsle/fnab067

Going to extremes - a metagenomic journey into the dark matter of life

Arnthór Aevarsson, Anna-Karina Kaczorowska, Björn Thor Adalsteinsson, Josefin Ahlqvist, Salam Al-Karadaghi, Joseph Altenbuchner, Hasan Arsin, Úlfur Áugúst Átlasson, David Brandt, Magdalena Cichowicz-Cieślak, Katy A S Cornish, Jérémy Courtin, Slawomir Dabrowski, Håkon Dahle, Samia Djeffane, Sebastian Dorawa, Julia Dusaucy, Francois Enault, Anita-Elin Fedøy, Stefanie Freitag-PohlOlafur H Fridjonsson, Clovis Galiez, Eirin Glomsaker, Mickael Guérin, Sigurd E Gundesø, Elisabet E Gudmundsdóttir, Hördur Gudmundsson, Maria Håkansson, Christian Henke, Alexandra Helleux, Jørn Remi Henriksen, Sigrídur Hjörleifdóttir, Gudmundur O Hreggvidsson, Andrius Jasilionis, Annika Jochheim, Ilmur Jónsdóttir, Lilja Björk Jónsdóttir, Agata Jurczak-Kurek, Tadeusz Kaczorowski, Jörn Kalinowski, Lukasz P Kozlowski, Mart Krupovic, Karolina Kwiatkowska-Semrau, Olav Lanes, Javier Linares-Pastén, Eva Nordberg Karlsson, Sigurlaug Skírnisdóttir, Anders Svensson, Björn Walse, Martin Welin, Ruoshi Zhang, Virus-X

Biophysical Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

The Virus-X-Viral Metagenomics for Innovation Value-project was a scientific expedition to explore and exploit uncharted territory of genetic diversity in extreme natural environments such as geothermal hot springs and deep-sea ocean ecosystems. Specifically, the project was set to analyse and exploit viral metagenomes with the ultimate goal of developing new gene products with high innovation value for applications in biotechnology, pharmaceutical, medical, and the life science sectors. Viral gene pool analysis is also essential to obtain fundamental insight into ecosystem dynamics and to investigate how viruses influence the evolution of microbes and multicellular organisms. The Virus-X Consortium, established in 2016, included experts from eight European countries. The unique approach based on high throughput bioinformatics technologies combined with structural and functional studies resulted in the development of a biodiscovery pipeline of significant capacity and scale. The activities within the Virus-X consortium cover the entire range from bioprospecting and methods development in bioinformatics to protein production and characterisation, with the final goal of translating our results into new products for the bioeconomy. The significant impact the consortium made in all of these areas was possible due to the successful cooperation between expert teams that worked together to solve a complex scientific problem using state-of-the-art technologies as well as developing novel tools to explore the virosphere, widely considered as the last great frontier of life.

Original language	English
Article number	fnab067
Number of pages	16
Journal	FEMS Microbiology Letters
Volume	368
Issue number	12
DOIs	https://doi.org/10.1093/femsle/fnab067
Publication status	Published - 2021 Jun 24

Subject classification (UKÄ)

Biochemistry and Molecular Biology

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10.1093/femsle/fnab067

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Aevarsson, A., Kaczorowska, A.-K., Adalsteinsson, B. T., Ahlqvist, J., Al-Karadaghi, S., Altenbuchner, J., Arsin, H., Átlasson, Ú. Á., Brandt, D., Cichowicz-Cieślak, M., Cornish, K. A. S., Courtin, J., Dabrowski, S., Dahle, H., Djeffane, S., Dorawa, S., Dusaucy, J., Enault, F., Fedøy, A.-E., ... Virus-X (2021). Going to extremes - a metagenomic journey into the dark matter of life. FEMS Microbiology Letters, 368(12), Article fnab067. https://doi.org/10.1093/femsle/fnab067

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title = "Going to extremes - a metagenomic journey into the dark matter of life",

abstract = "The Virus-X-Viral Metagenomics for Innovation Value-project was a scientific expedition to explore and exploit uncharted territory of genetic diversity in extreme natural environments such as geothermal hot springs and deep-sea ocean ecosystems. Specifically, the project was set to analyse and exploit viral metagenomes with the ultimate goal of developing new gene products with high innovation value for applications in biotechnology, pharmaceutical, medical, and the life science sectors. Viral gene pool analysis is also essential to obtain fundamental insight into ecosystem dynamics and to investigate how viruses influence the evolution of microbes and multicellular organisms. The Virus-X Consortium, established in 2016, included experts from eight European countries. The unique approach based on high throughput bioinformatics technologies combined with structural and functional studies resulted in the development of a biodiscovery pipeline of significant capacity and scale. The activities within the Virus-X consortium cover the entire range from bioprospecting and methods development in bioinformatics to protein production and characterisation, with the final goal of translating our results into new products for the bioeconomy. The significant impact the consortium made in all of these areas was possible due to the successful cooperation between expert teams that worked together to solve a complex scientific problem using state-of-the-art technologies as well as developing novel tools to explore the virosphere, widely considered as the last great frontier of life.",

author = "Arnth{\'o}r Aevarsson and Anna-Karina Kaczorowska and Adalsteinsson, {Bj{\"o}rn Thor} and Josefin Ahlqvist and Salam Al-Karadaghi and Joseph Altenbuchner and Hasan Arsin and {\'A}tlasson, {{\'U}lfur {\'A}ug{\'u}st} and David Brandt and Magdalena Cichowicz-Cie{\'s}lak and Cornish, {Katy A S} and J{\'e}r{\'e}my Courtin and Slawomir Dabrowski and H{\aa}kon Dahle and Samia Djeffane and Sebastian Dorawa and Julia Dusaucy and Francois Enault and Anita-Elin Fed{\o}y and Stefanie Freitag-Pohl and Fridjonsson, {Olafur H} and Clovis Galiez and Eirin Glomsaker and Mickael Gu{\'e}rin and Gundes{\o}, {Sigurd E} and Gudmundsd{\'o}ttir, {Elisabet E} and H{\"o}rdur Gudmundsson and Maria H{\aa}kansson and Christian Henke and Alexandra Helleux and Henriksen, {J{\o}rn Remi} and Sigr{\'i}dur Hj{\"o}rleifd{\'o}ttir and Hreggvidsson, {Gudmundur O} and Andrius Jasilionis and Annika Jochheim and Ilmur J{\'o}nsd{\'o}ttir and J{\'o}nsd{\'o}ttir, {Lilja Bj{\"o}rk} and Agata Jurczak-Kurek and Tadeusz Kaczorowski and J{\"o}rn Kalinowski and Kozlowski, {Lukasz P} and Mart Krupovic and Karolina Kwiatkowska-Semrau and Olav Lanes and Javier Linares-Past{\'e}n and Karlsson, {Eva Nordberg} and Sigurlaug Sk{\'i}rnisd{\'o}ttir and Anders Svensson and Bj{\"o}rn Walse and Martin Welin and Ruoshi Zhang and Virus-X",

year = "2021",

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doi = "10.1093/femsle/fnab067",

language = "English",

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Aevarsson, A, Kaczorowska, A-K, Adalsteinsson, BT, Ahlqvist, J , Al-Karadaghi, S, Altenbuchner, J, Arsin, H, Átlasson, ÚÁ, Brandt, D, Cichowicz-Cieślak, M, Cornish, KAS, Courtin, J, Dabrowski, S, Dahle, H, Djeffane, S, Dorawa, S, Dusaucy, J, Enault, F, Fedøy, A-E, Freitag-Pohl, S, Fridjonsson, OH, Galiez, C, Glomsaker, E, Guérin, M, Gundesø, SE, Gudmundsdóttir, EE, Gudmundsson, H, Håkansson, M, Henke, C, Helleux, A, Henriksen, JR, Hjörleifdóttir, S, Hreggvidsson, GO, Jasilionis, A, Jochheim, A, Jónsdóttir, I, Jónsdóttir, LB, Jurczak-Kurek, A, Kaczorowski, T, Kalinowski, J, Kozlowski, LP, Krupovic, M, Kwiatkowska-Semrau, K, Lanes, O, Linares-Pastén, J , Karlsson, EN, Skírnisdóttir, S, Svensson, A, Walse, B, Welin, M, Zhang, R & Virus-X 2021, 'Going to extremes - a metagenomic journey into the dark matter of life', FEMS Microbiology Letters, vol. 368, no. 12, fnab067. https://doi.org/10.1093/femsle/fnab067

TY - JOUR

T1 - Going to extremes - a metagenomic journey into the dark matter of life

AU - Aevarsson, Arnthór

AU - Kaczorowska, Anna-Karina

AU - Adalsteinsson, Björn Thor

AU - Ahlqvist, Josefin

AU - Al-Karadaghi, Salam

AU - Altenbuchner, Joseph

AU - Arsin, Hasan

AU - Átlasson, Úlfur Áugúst

AU - Brandt, David

AU - Cichowicz-Cieślak, Magdalena

AU - Cornish, Katy A S

AU - Courtin, Jérémy

AU - Dabrowski, Slawomir

AU - Dahle, Håkon

AU - Djeffane, Samia

AU - Dorawa, Sebastian

AU - Dusaucy, Julia

AU - Enault, Francois

AU - Fedøy, Anita-Elin

AU - Freitag-Pohl, Stefanie

AU - Fridjonsson, Olafur H

AU - Galiez, Clovis

AU - Glomsaker, Eirin

AU - Guérin, Mickael

AU - Gundesø, Sigurd E

AU - Gudmundsdóttir, Elisabet E

AU - Gudmundsson, Hördur

AU - Håkansson, Maria

AU - Henke, Christian

AU - Helleux, Alexandra

AU - Henriksen, Jørn Remi

AU - Hjörleifdóttir, Sigrídur

AU - Hreggvidsson, Gudmundur O

AU - Jasilionis, Andrius

AU - Jochheim, Annika

AU - Jónsdóttir, Ilmur

AU - Jónsdóttir, Lilja Björk

AU - Jurczak-Kurek, Agata

AU - Kaczorowski, Tadeusz

AU - Kalinowski, Jörn

AU - Kozlowski, Lukasz P

AU - Krupovic, Mart

AU - Kwiatkowska-Semrau, Karolina

AU - Lanes, Olav

AU - Linares-Pastén, Javier

AU - Karlsson, Eva Nordberg

AU - Skírnisdóttir, Sigurlaug

AU - Svensson, Anders

AU - Walse, Björn

AU - Welin, Martin

AU - Zhang, Ruoshi

AU - Virus-X

PY - 2021/6/24

Y1 - 2021/6/24

N2 - The Virus-X-Viral Metagenomics for Innovation Value-project was a scientific expedition to explore and exploit uncharted territory of genetic diversity in extreme natural environments such as geothermal hot springs and deep-sea ocean ecosystems. Specifically, the project was set to analyse and exploit viral metagenomes with the ultimate goal of developing new gene products with high innovation value for applications in biotechnology, pharmaceutical, medical, and the life science sectors. Viral gene pool analysis is also essential to obtain fundamental insight into ecosystem dynamics and to investigate how viruses influence the evolution of microbes and multicellular organisms. The Virus-X Consortium, established in 2016, included experts from eight European countries. The unique approach based on high throughput bioinformatics technologies combined with structural and functional studies resulted in the development of a biodiscovery pipeline of significant capacity and scale. The activities within the Virus-X consortium cover the entire range from bioprospecting and methods development in bioinformatics to protein production and characterisation, with the final goal of translating our results into new products for the bioeconomy. The significant impact the consortium made in all of these areas was possible due to the successful cooperation between expert teams that worked together to solve a complex scientific problem using state-of-the-art technologies as well as developing novel tools to explore the virosphere, widely considered as the last great frontier of life.

AB - The Virus-X-Viral Metagenomics for Innovation Value-project was a scientific expedition to explore and exploit uncharted territory of genetic diversity in extreme natural environments such as geothermal hot springs and deep-sea ocean ecosystems. Specifically, the project was set to analyse and exploit viral metagenomes with the ultimate goal of developing new gene products with high innovation value for applications in biotechnology, pharmaceutical, medical, and the life science sectors. Viral gene pool analysis is also essential to obtain fundamental insight into ecosystem dynamics and to investigate how viruses influence the evolution of microbes and multicellular organisms. The Virus-X Consortium, established in 2016, included experts from eight European countries. The unique approach based on high throughput bioinformatics technologies combined with structural and functional studies resulted in the development of a biodiscovery pipeline of significant capacity and scale. The activities within the Virus-X consortium cover the entire range from bioprospecting and methods development in bioinformatics to protein production and characterisation, with the final goal of translating our results into new products for the bioeconomy. The significant impact the consortium made in all of these areas was possible due to the successful cooperation between expert teams that worked together to solve a complex scientific problem using state-of-the-art technologies as well as developing novel tools to explore the virosphere, widely considered as the last great frontier of life.

U2 - 10.1093/femsle/fnab067

DO - 10.1093/femsle/fnab067

M3 - Review article

C2 - 34114607

SN - 1574-6968

VL - 368

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

IS - 12

M1 - fnab067

ER -

Going to extremes - a metagenomic journey into the dark matter of life

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