Gonadal sex steroid status and bone health in middle-aged and elderly European men

D. Vanderschueren; S. R. Pye; K. Venken; H. Borghs; J. Gaytant; I. T. Huhtaniemi; J. E. Adams; K. A. Ward; G. Bartfai; F. F. Casanueva; J. D. Finn; G. Forti; Aleksander Giwercman; T. S. Han; K. Kula; F. Labrie; M. E. J. Lean; N. Pendleton; M. Punab; A. J. Silman; F. C. W. Wu; T. W. O'Neill; S. Boonen

doi:10.1007/s00198-009-1144-2

Gonadal sex steroid status and bone health in middle-aged and elderly European men

D. Vanderschueren, S. R. Pye, K. Venken, H. Borghs, J. Gaytant, I. T. Huhtaniemi, J. E. Adams, K. A. Ward, G. Bartfai, F. F. Casanueva, J. D. Finn, G. Forti, Aleksander Giwercman, T. S. Han, K. Kula, F. Labrie, M. E. J. Lean, N. Pendleton, M. Punab, A. J. SilmanF. C. W. Wu, T. W. O'Neill, S. Boonen

Reproductive medicine, Malmö

Research output: Contribution to journal › Article › peer-review

Abstract

The influence of sex steroids on calcaneal quantitative ultrasound (QUS) parameters was assessed in a population sample of middle-aged and elderly European men. Higher free and total E-2 though not testosterone, were independently associated with higher QUS parameters. The aim of this study was to investigate the association between QUS parameters and sex steroids in middle-aged and elderly European men. Three thousand one hundred forty-one men aged between 40 and 79 years were recruited from eight European centres for participation in a study of male ageing: the European Male Ageing Study. Subjects were invited by letter to attend for an interviewer-administered questionnaire, blood sample and QUS of the calcaneus (Hologic-SAHARA). Blood was assessed for sex steroids including oestradiol (E-2), testosterone (T), free and bio-available E-2 and T and sex hormone binding globulin (SHBG). Serum total T was not associated with any of the QUS parameters. Free T and both free and total E-2 were positively related to all QUS readings, while SHBG concentrations were negatively associated. These relationships were observed in both older and younger (< 60 years) men. In a multivariate model, after adjustment for age, centre, height, weight, physical activity levels and smoking, free E-2 and SHBG, though not free T, remained independently associated with the QUS parameters. After further adjustment for IGF-1, however, the association with SHBG became non-significant. Higher free and total E-2 are associated with bone health not only among the elderly but also middle-aged European men.

Original language	English
Pages (from-to)	1331-1339
Journal	Osteoporosis International
Volume	21
Issue number	8
DOIs	https://doi.org/10.1007/s00198-009-1144-2
Publication status	Published - 2010

Subject classification (UKÄ)

Obstetrics, Gynecology and Reproductive Medicine

Free keywords

Testosterone
SHBG
Sex steroids
Epidemiology
Oestradiol
Ultrasound

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10.1007/s00198-009-1144-2

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Vanderschueren, D., Pye, S. R., Venken, K., Borghs, H., Gaytant, J., Huhtaniemi, I. T., Adams, J. E., Ward, K. A., Bartfai, G., Casanueva, F. F., Finn, J. D., Forti, G., Giwercman, A., Han, T. S., Kula, K., Labrie, F., Lean, M. E. J., Pendleton, N., Punab, M., ... Boonen, S. (2010). Gonadal sex steroid status and bone health in middle-aged and elderly European men. Osteoporosis International, 21(8), 1331-1339. https://doi.org/10.1007/s00198-009-1144-2

@article{e2c62a55b5e54e4289bcc47d1aeed876,

title = "Gonadal sex steroid status and bone health in middle-aged and elderly European men",

abstract = "The influence of sex steroids on calcaneal quantitative ultrasound (QUS) parameters was assessed in a population sample of middle-aged and elderly European men. Higher free and total E-2 though not testosterone, were independently associated with higher QUS parameters. The aim of this study was to investigate the association between QUS parameters and sex steroids in middle-aged and elderly European men. Three thousand one hundred forty-one men aged between 40 and 79 years were recruited from eight European centres for participation in a study of male ageing: the European Male Ageing Study. Subjects were invited by letter to attend for an interviewer-administered questionnaire, blood sample and QUS of the calcaneus (Hologic-SAHARA). Blood was assessed for sex steroids including oestradiol (E-2), testosterone (T), free and bio-available E-2 and T and sex hormone binding globulin (SHBG). Serum total T was not associated with any of the QUS parameters. Free T and both free and total E-2 were positively related to all QUS readings, while SHBG concentrations were negatively associated. These relationships were observed in both older and younger (< 60 years) men. In a multivariate model, after adjustment for age, centre, height, weight, physical activity levels and smoking, free E-2 and SHBG, though not free T, remained independently associated with the QUS parameters. After further adjustment for IGF-1, however, the association with SHBG became non-significant. Higher free and total E-2 are associated with bone health not only among the elderly but also middle-aged European men.",

keywords = "Testosterone, SHBG, Sex steroids, Epidemiology, Oestradiol, Ultrasound",

author = "D. Vanderschueren and Pye, {S. R.} and K. Venken and H. Borghs and J. Gaytant and Huhtaniemi, {I. T.} and Adams, {J. E.} and Ward, {K. A.} and G. Bartfai and Casanueva, {F. F.} and Finn, {J. D.} and G. Forti and Aleksander Giwercman and Han, {T. S.} and K. Kula and F. Labrie and Lean, {M. E. J.} and N. Pendleton and M. Punab and Silman, {A. J.} and Wu, {F. C. W.} and O'Neill, {T. W.} and S. Boonen",

year = "2010",

doi = "10.1007/s00198-009-1144-2",

language = "English",

volume = "21",

pages = "1331--1339",

journal = "Osteoporosis International",

issn = "1433-2965",

publisher = "Springer",

number = "8",

}

Vanderschueren, D, Pye, SR, Venken, K, Borghs, H, Gaytant, J, Huhtaniemi, IT, Adams, JE, Ward, KA, Bartfai, G, Casanueva, FF, Finn, JD, Forti, G, Giwercman, A, Han, TS, Kula, K, Labrie, F, Lean, MEJ, Pendleton, N, Punab, M, Silman, AJ, Wu, FCW, O'Neill, TW & Boonen, S 2010, 'Gonadal sex steroid status and bone health in middle-aged and elderly European men', Osteoporosis International, vol. 21, no. 8, pp. 1331-1339. https://doi.org/10.1007/s00198-009-1144-2

TY - JOUR

T1 - Gonadal sex steroid status and bone health in middle-aged and elderly European men

AU - Vanderschueren, D.

AU - Pye, S. R.

AU - Venken, K.

AU - Borghs, H.

AU - Gaytant, J.

AU - Huhtaniemi, I. T.

AU - Adams, J. E.

AU - Ward, K. A.

AU - Bartfai, G.

AU - Casanueva, F. F.

AU - Finn, J. D.

AU - Forti, G.

AU - Giwercman, Aleksander

AU - Han, T. S.

AU - Kula, K.

AU - Labrie, F.

AU - Lean, M. E. J.

AU - Pendleton, N.

AU - Punab, M.

AU - Silman, A. J.

AU - Wu, F. C. W.

AU - O'Neill, T. W.

AU - Boonen, S.

PY - 2010

Y1 - 2010

N2 - The influence of sex steroids on calcaneal quantitative ultrasound (QUS) parameters was assessed in a population sample of middle-aged and elderly European men. Higher free and total E-2 though not testosterone, were independently associated with higher QUS parameters. The aim of this study was to investigate the association between QUS parameters and sex steroids in middle-aged and elderly European men. Three thousand one hundred forty-one men aged between 40 and 79 years were recruited from eight European centres for participation in a study of male ageing: the European Male Ageing Study. Subjects were invited by letter to attend for an interviewer-administered questionnaire, blood sample and QUS of the calcaneus (Hologic-SAHARA). Blood was assessed for sex steroids including oestradiol (E-2), testosterone (T), free and bio-available E-2 and T and sex hormone binding globulin (SHBG). Serum total T was not associated with any of the QUS parameters. Free T and both free and total E-2 were positively related to all QUS readings, while SHBG concentrations were negatively associated. These relationships were observed in both older and younger (< 60 years) men. In a multivariate model, after adjustment for age, centre, height, weight, physical activity levels and smoking, free E-2 and SHBG, though not free T, remained independently associated with the QUS parameters. After further adjustment for IGF-1, however, the association with SHBG became non-significant. Higher free and total E-2 are associated with bone health not only among the elderly but also middle-aged European men.

AB - The influence of sex steroids on calcaneal quantitative ultrasound (QUS) parameters was assessed in a population sample of middle-aged and elderly European men. Higher free and total E-2 though not testosterone, were independently associated with higher QUS parameters. The aim of this study was to investigate the association between QUS parameters and sex steroids in middle-aged and elderly European men. Three thousand one hundred forty-one men aged between 40 and 79 years were recruited from eight European centres for participation in a study of male ageing: the European Male Ageing Study. Subjects were invited by letter to attend for an interviewer-administered questionnaire, blood sample and QUS of the calcaneus (Hologic-SAHARA). Blood was assessed for sex steroids including oestradiol (E-2), testosterone (T), free and bio-available E-2 and T and sex hormone binding globulin (SHBG). Serum total T was not associated with any of the QUS parameters. Free T and both free and total E-2 were positively related to all QUS readings, while SHBG concentrations were negatively associated. These relationships were observed in both older and younger (< 60 years) men. In a multivariate model, after adjustment for age, centre, height, weight, physical activity levels and smoking, free E-2 and SHBG, though not free T, remained independently associated with the QUS parameters. After further adjustment for IGF-1, however, the association with SHBG became non-significant. Higher free and total E-2 are associated with bone health not only among the elderly but also middle-aged European men.

KW - Testosterone

KW - SHBG

KW - Sex steroids

KW - Epidemiology

KW - Oestradiol

KW - Ultrasound

U2 - 10.1007/s00198-009-1144-2

DO - 10.1007/s00198-009-1144-2

M3 - Article

C2 - 20012940

SN - 1433-2965

VL - 21

SP - 1331

EP - 1339

JO - Osteoporosis International

JF - Osteoporosis International

IS - 8

ER -

Gonadal sex steroid status and bone health in middle-aged and elderly European men

Abstract

Subject classification (UKÄ)

Free keywords

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