Abstract
Benbarche, Pineda, Galvis, et al. delineate an essential role for the G-patch motif-containing protein GPATCH8 in mis-splicing associated with cancer-driving mutations of the splicing factor SF3B1. GPATCH8 cooperates with SF3B1 mutants, affecting the splicing machinery. Targeting GPATCH8 reveals therapeutic opportunities for SF3B1 mutant cancers and other splicing-related diseases.
Original language | English |
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Pages (from-to) | 564-566 |
Number of pages | 3 |
Journal | Trends in Biochemical Sciences |
Volume | 49 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2024 Jul |
Subject classification (UKÄ)
- Cancer and Oncology
Free keywords
- DHX15
- G-patch domain
- GPATCH8
- SF3B1
- splicing
- SUGP1