Abstract

Benbarche, Pineda, Galvis, et al. delineate an essential role for the G-patch motif-containing protein GPATCH8 in mis-splicing associated with cancer-driving mutations of the splicing factor SF3B1. GPATCH8 cooperates with SF3B1 mutants, affecting the splicing machinery. Targeting GPATCH8 reveals therapeutic opportunities for SF3B1 mutant cancers and other splicing-related diseases.

Original languageEnglish
Pages (from-to)564-566
Number of pages3
JournalTrends in Biochemical Sciences
Volume49
Issue number7
DOIs
Publication statusPublished - 2024 Jul

Subject classification (UKÄ)

  • Cancer and Oncology

Free keywords

  • DHX15
  • G-patch domain
  • GPATCH8
  • SF3B1
  • splicing
  • SUGP1

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