GPR30/GPER1: searching for a role in estrogen physiology.

Björn Olde; Fredrik Leeb-Lundberg

doi:10.1016/j.tem.2009.04.006

GPR30/GPER1: searching for a role in estrogen physiology.

Research output: Contribution to journal › Article › peer-review

Abstract

Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomic estrogen signaling. However, this function is not universally accepted. Studies concerning the role of GPER1 in vivo are now beginning to appear but with divergent results. In this review we discuss current knowledge on the physiological role of GPER1 in the nervous system as well as in reproduction, metabolism, bone, and in the cardiovascular and immune systems.

Original language	English
Pages (from-to)	409-416
Journal	Trends in Endocrinology and Metabolism
Volume	20
DOIs	https://doi.org/10.1016/j.tem.2009.04.006
Publication status	Published - 2009

Subject classification (UKÄ)

Endocrinology and Diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tem.2009.04.006

http://www.ncbi.nlm.nih.gov/pubmed/19734054?dopt=Abstract

Cite this

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title = "GPR30/GPER1: searching for a role in estrogen physiology.",

abstract = "Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomic estrogen signaling. However, this function is not universally accepted. Studies concerning the role of GPER1 in vivo are now beginning to appear but with divergent results. In this review we discuss current knowledge on the physiological role of GPER1 in the nervous system as well as in reproduction, metabolism, bone, and in the cardiovascular and immune systems.",

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AU - Leeb-Lundberg, Fredrik

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JF - Trends in Endocrinology and Metabolism

ER -

GPR30/GPER1: searching for a role in estrogen physiology.

Abstract

Subject classification (UKÄ)

UN SDGs

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