Granulocyte Colony-Stimulating Factor in Patients With Acute Ischemic Stroke: Results of the AX200 for Ischemic Stroke Trial.

E Bernd Ringelstein; Vincent Thijs; Bo Norrving; Angel Chamorro; Franz Aichner; Martin Grond; Jeff Saver; Rico Laage; Armin Schneider; Frank Rathgeb; Gerhard Vogt; Gabriele Charissé; Jochen B Fiebach; Stefan Schwab; Wolf R Schäbitz; Rainer Kollmar; Marc Fisher; Miroslav Brozman; David Skoloudik; Franz Gruber; Joaquin Serena Leal; Roland Veltkamp; Martin Köhrmann; Jörg Berrouschot

doi:10.1161/STROKEAHA.113.001531

Granulocyte Colony-Stimulating Factor in Patients With Acute Ischemic Stroke: Results of the AX200 for Ischemic Stroke Trial.

E Bernd Ringelstein, Vincent Thijs, Bo Norrving, Angel Chamorro, Franz Aichner, Martin Grond, Jeff Saver, Rico Laage, Armin Schneider, Frank Rathgeb, Gerhard Vogt, Gabriele Charissé, Jochen B Fiebach, Stefan Schwab, Wolf R Schäbitz, Rainer Kollmar, Marc Fisher, Miroslav Brozman, David Skoloudik, Franz GruberJoaquin Serena Leal, Roland Veltkamp, Martin Köhrmann, Jörg Berrouschot

Neurology, Lund

Research output: Contribution to journal › Article › peer-review

Abstract

Granulocyte colony-stimulating factor (G-CSF; AX200; Filgrastim) is a stroke drug candidate with excellent preclinical evidence for efficacy. A previous phase IIa dose-escalation study suggested potential efficacy in humans. The present large phase IIb trial was powered to detect clinical efficacy in acute ischemic stroke patients.

Original language	English
Pages (from-to)	2681-2687
Journal	Stroke: a journal of cerebral circulation
Volume	44
Issue number	10
DOIs	https://doi.org/10.1161/STROKEAHA.113.001531
Publication status	Published - 2013

Subject classification (UKÄ)

Neurology

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10.1161/STROKEAHA.113.001531

http://www.ncbi.nlm.nih.gov/pubmed/23963331?dopt=Abstract

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Ringelstein, E. B., Thijs, V., Norrving, B., Chamorro, A., Aichner, F., Grond, M., Saver, J., Laage, R., Schneider, A., Rathgeb, F., Vogt, G., Charissé, G., Fiebach, J. B., Schwab, S., Schäbitz, W. R., Kollmar, R., Fisher, M., Brozman, M., Skoloudik, D., ... Berrouschot, J. (2013). Granulocyte Colony-Stimulating Factor in Patients With Acute Ischemic Stroke: Results of the AX200 for Ischemic Stroke Trial. Stroke: a journal of cerebral circulation, 44(10), 2681-2687. https://doi.org/10.1161/STROKEAHA.113.001531

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title = "Granulocyte Colony-Stimulating Factor in Patients With Acute Ischemic Stroke: Results of the AX200 for Ischemic Stroke Trial.",

abstract = "Granulocyte colony-stimulating factor (G-CSF; AX200; Filgrastim) is a stroke drug candidate with excellent preclinical evidence for efficacy. A previous phase IIa dose-escalation study suggested potential efficacy in humans. The present large phase IIb trial was powered to detect clinical efficacy in acute ischemic stroke patients.",

author = "Ringelstein, {E Bernd} and Vincent Thijs and Bo Norrving and Angel Chamorro and Franz Aichner and Martin Grond and Jeff Saver and Rico Laage and Armin Schneider and Frank Rathgeb and Gerhard Vogt and Gabriele Chariss{\'e} and Fiebach, {Jochen B} and Stefan Schwab and Sch{\"a}bitz, {Wolf R} and Rainer Kollmar and Marc Fisher and Miroslav Brozman and David Skoloudik and Franz Gruber and Leal, {Joaquin Serena} and Roland Veltkamp and Martin K{\"o}hrmann and J{\"o}rg Berrouschot",

year = "2013",

doi = "10.1161/STROKEAHA.113.001531",

language = "English",

volume = "44",

pages = "2681--2687",

journal = "Stroke: a journal of cerebral circulation",

issn = "1524-4628",

publisher = "American Heart Association",

number = "10",

}

Ringelstein, EB, Thijs, V, Norrving, B, Chamorro, A, Aichner, F, Grond, M, Saver, J, Laage, R, Schneider, A, Rathgeb, F, Vogt, G, Charissé, G, Fiebach, JB, Schwab, S, Schäbitz, WR, Kollmar, R, Fisher, M, Brozman, M, Skoloudik, D, Gruber, F, Leal, JS, Veltkamp, R, Köhrmann, M & Berrouschot, J 2013, 'Granulocyte Colony-Stimulating Factor in Patients With Acute Ischemic Stroke: Results of the AX200 for Ischemic Stroke Trial.', Stroke: a journal of cerebral circulation, vol. 44, no. 10, pp. 2681-2687. https://doi.org/10.1161/STROKEAHA.113.001531

TY - JOUR

T1 - Granulocyte Colony-Stimulating Factor in Patients With Acute Ischemic Stroke: Results of the AX200 for Ischemic Stroke Trial.

AU - Ringelstein, E Bernd

AU - Thijs, Vincent

AU - Norrving, Bo

AU - Chamorro, Angel

AU - Aichner, Franz

AU - Grond, Martin

AU - Saver, Jeff

AU - Laage, Rico

AU - Schneider, Armin

AU - Rathgeb, Frank

AU - Vogt, Gerhard

AU - Charissé, Gabriele

AU - Fiebach, Jochen B

AU - Schwab, Stefan

AU - Schäbitz, Wolf R

AU - Kollmar, Rainer

AU - Fisher, Marc

AU - Brozman, Miroslav

AU - Skoloudik, David

AU - Gruber, Franz

AU - Leal, Joaquin Serena

AU - Veltkamp, Roland

AU - Köhrmann, Martin

AU - Berrouschot, Jörg

PY - 2013

Y1 - 2013

N2 - Granulocyte colony-stimulating factor (G-CSF; AX200; Filgrastim) is a stroke drug candidate with excellent preclinical evidence for efficacy. A previous phase IIa dose-escalation study suggested potential efficacy in humans. The present large phase IIb trial was powered to detect clinical efficacy in acute ischemic stroke patients.

AB - Granulocyte colony-stimulating factor (G-CSF; AX200; Filgrastim) is a stroke drug candidate with excellent preclinical evidence for efficacy. A previous phase IIa dose-escalation study suggested potential efficacy in humans. The present large phase IIb trial was powered to detect clinical efficacy in acute ischemic stroke patients.

U2 - 10.1161/STROKEAHA.113.001531

DO - 10.1161/STROKEAHA.113.001531

M3 - Article

C2 - 23963331

SN - 1524-4628

VL - 44

SP - 2681

EP - 2687

JO - Stroke: a journal of cerebral circulation

JF - Stroke: a journal of cerebral circulation

IS - 10

ER -

Granulocyte Colony-Stimulating Factor in Patients With Acute Ischemic Stroke: Results of the AX200 for Ischemic Stroke Trial.

Abstract

Subject classification (UKÄ)

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