Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.

Viveka Schaar; Ida Uddbäck; Therése Nordström; Kristian Riesbeck

doi:10.1093/jac/dkt307

Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.

Viveka Schaar, Ida Uddbäck, Therése Nordström, Kristian Riesbeck

Clinical Microbiology, Malmö

Research output: Contribution to journal › Article › peer-review

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Abstract

Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.

Original language	English
Pages (from-to)	117-120
Journal	Journal of Antimicrobial Chemotherapy
Volume	69
Issue number	1
DOIs	https://doi.org/10.1093/jac/dkt307
Publication status	Published - 2014

Subject classification (UKÄ)

Pharmacology and Toxicology

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10.1093/jac/dkt307

OUP_Schaar_et_al

http://www.ncbi.nlm.nih.gov/pubmed/23912886?dopt=Abstract

1 Doctoral Thesis (compilation)

Bacterial Outer Membrane Vesicles. Mediators of virulence and antibiotic resistance.
Schaar, V., 2013, Medical Microbiology, Lund University.
Research output: Thesis › Doctoral Thesis (compilation)

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title = "Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.",

abstract = "Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.",

author = "Viveka Schaar and Ida Uddb{\"a}ck and Ther{\'e}se Nordstr{\"o}m and Kristian Riesbeck",

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language = "English",

volume = "69",

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journal = "Journal of Antimicrobial Chemotherapy",

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T1 - Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.

AU - Schaar, Viveka

AU - Uddbäck, Ida

AU - Nordström, Therése

AU - Riesbeck, Kristian

PY - 2014

Y1 - 2014

N2 - Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.

AB - Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.

U2 - 10.1093/jac/dkt307

DO - 10.1093/jac/dkt307

M3 - Article

SN - 1460-2091

VL - 69

SP - 117

EP - 120

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 1

ER -

Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.

Abstract

Subject classification (UKÄ)

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Research output

Bacterial Outer Membrane Vesicles. Mediators of virulence and antibiotic resistance.

Cite this