Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells

Sara Lombardi; Gabriella Honeth; Christophe Ginestier; Ireneusz Shinomiya; Rebecca Marlow; Bharath Buchupalli; Patrycja Gazinska; John Brown; Steven Catchpole; Suling Liu; Ariel Barkan; Max Wicha; Anand Purushotham; Joy Burchell; Sarah Pinder; Gabriela Dontu

doi:10.1016/j.stemcr.2014.05.005

Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells

Sara Lombardi, Gabriella Honeth, Christophe Ginestier, Ireneusz Shinomiya, Rebecca Marlow, Bharath Buchupalli, Patrycja Gazinska, John Brown, Steven Catchpole, Suling Liu, Ariel Barkan, Max Wicha, Anand Purushotham, Joy Burchell, Sarah Pinder, Gabriela Dontu

Molecular therapeutics in breast cancer

King's College London

Research output: Contribution to journal › Article › peer-review

Abstract

Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.

Original language	English
Pages (from-to)	780-93
Number of pages	14
Journal	Stem Cell Reports
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/j.stemcr.2014.05.005
Publication status	Published - 2014 Jun 3

Free keywords

Cell Proliferation
Cells, Cultured
Human Growth Hormone
Humans
Mammary Glands, Human
Progesterone
Stem Cells
Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.stemcr.2014.05.005

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Lombardi, S., Honeth, G., Ginestier, C., Shinomiya, I., Marlow, R., Buchupalli, B., Gazinska, P., Brown, J., Catchpole, S., Liu, S., Barkan, A., Wicha, M., Purushotham, A., Burchell, J., Pinder, S., & Dontu, G. (2014). Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells. Stem Cell Reports, 2(6), 780-93. https://doi.org/10.1016/j.stemcr.2014.05.005

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title = "Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells",

abstract = "Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.",

keywords = "Cell Proliferation, Cells, Cultured, Human Growth Hormone, Humans, Mammary Glands, Human, Progesterone, Stem Cells, Journal Article, Research Support, Non-U.S. Gov't",

author = "Sara Lombardi and Gabriella Honeth and Christophe Ginestier and Ireneusz Shinomiya and Rebecca Marlow and Bharath Buchupalli and Patrycja Gazinska and John Brown and Steven Catchpole and Suling Liu and Ariel Barkan and Max Wicha and Anand Purushotham and Joy Burchell and Sarah Pinder and Gabriela Dontu",

year = "2014",

month = jun,

day = "3",

doi = "10.1016/j.stemcr.2014.05.005",

language = "English",

volume = "2",

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journal = "Stem Cell Reports",

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Lombardi, S, Honeth, G, Ginestier, C, Shinomiya, I, Marlow, R, Buchupalli, B, Gazinska, P, Brown, J, Catchpole, S, Liu, S, Barkan, A, Wicha, M, Purushotham, A, Burchell, J, Pinder, S & Dontu, G 2014, 'Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells', Stem Cell Reports, vol. 2, no. 6, pp. 780-93. https://doi.org/10.1016/j.stemcr.2014.05.005

TY - JOUR

T1 - Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells

AU - Lombardi, Sara

AU - Honeth, Gabriella

AU - Ginestier, Christophe

AU - Shinomiya, Ireneusz

AU - Marlow, Rebecca

AU - Buchupalli, Bharath

AU - Gazinska, Patrycja

AU - Brown, John

AU - Catchpole, Steven

AU - Liu, Suling

AU - Barkan, Ariel

AU - Wicha, Max

AU - Purushotham, Anand

AU - Burchell, Joy

AU - Pinder, Sarah

AU - Dontu, Gabriela

PY - 2014/6/3

Y1 - 2014/6/3

N2 - Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.

AB - Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.

KW - Cell Proliferation

KW - Cells, Cultured

KW - Human Growth Hormone

KW - Humans

KW - Mammary Glands, Human

KW - Progesterone

KW - Stem Cells

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.stemcr.2014.05.005

DO - 10.1016/j.stemcr.2014.05.005

M3 - Article

C2 - 24936466

SN - 2213-6711

VL - 2

SP - 780

EP - 793

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 6

ER -

Growth hormone is secreted by normal breast epithelium upon progesterone stimulation and increases proliferation of stem/progenitor cells

Abstract

Free keywords

UN SDGs

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