Health in middle-aged women, with emphasis on features of the metabolic syndrome and related markers for diabetes. Women´s Health in the Lund Area Study.

Jonas Lidfeldt

Health in middle-aged women, with emphasis on features of the metabolic syndrome and related markers for diabetes. Women´s Health in the Lund Area Study.

Jonas Lidfeldt

Family Medicine and Community Medicine

Research output: Thesis › Doctoral Thesis (compilation)

Abstract

The aims were to study the biological, socio-demographic and psychosocial health profile in a geographically defined population of middle-aged women, with focus on features of the metabolic syndrome and diabetes, and to study the efficiency of a screening method for high-risk individuals and the outcome of baseline lifestyle advices on the diabetes incidence.

All women aged 50-59 years (n=10766) were invited to a screening procedure including questionnaires and laboratory assessments. Subjects were discriminated as positive or negative on one to eight variables linked to the metabolic syndrome. Those with positive screening and impaired glucose tolerance (IGT) at oral glucose tolerance test, were followed for 2.5 years after a one-hour session of lifestyle advices. A sub-sample of women with negative screening and normal glucose tolerance (NGT) were also studied at follow-up.

Altogether, 6917 women attended the study and 93% were postmenopausal. Nearly half had hormone replacement therapy (HRT). A positive screening profile was found in 51%, and 14% had IGT and 6,4% diabetes, out of whom 4.8% were previously unknown. High blood glucose, waist hip ratio and body mass index were the most important factors associated with glucose intolerance. The screening instrument showed a sensitivity of 80% and a specificity of 55%. A total of 27% had hypertension. The prevalence of osteoporosis was 6.6%. In the longitudinal study, 11.9% of women with IGT developed diabetes, while 38% turned normal. In the group with NGT no one developed diabetes. Biological factors interrelated with socio-demographic and psychosocial disparities, like low level of education, living single and low subjective physical well-being. Low or moderate alcohol consumption seemed beneficial on the metabolic profile. The results on smoking and HRT were contradictory concerning the effect on features of the metabolic syndrome, while more crucial for the bone density.

A high prevalence of risk variables was found, and many cases of IGT and diabetes. Screening of women at high risk for diabetes should be performed, and the biological risk profile considered jointly with socio-demographic and psychosocial factors. A one-hour baseline occasion of lifestyle advices reduces significantly the risk for new cases of diabetes.

Translated title of the contribution	Medelålders kvinnors hälsa, med fokus på metabola syndromet och andra faktorer kopplade till diabetes.
Original language	English
Qualification	Doctor
Awarding Institution	Department of Health Sciences
Supervisors/Advisors	[unknown], [unknown], Supervisor, External person
Award date	2003 Apr 11
Publisher	Jonas Lidfeldt, FoUU Primary Health Care, University Hospital Lund, 221 85 Lund,
ISBN (Print)	91-628-5562-X
Publication status	Published - 2003

Bibliographical note

Defence details

Date: 2003-04-11
Time: 10:15
Place: Jubileumsaulan, Ingång 59, UMAS

External reviewer(s)

Name: Östenson, Claes-Göran
Title: Prof.
Affiliation: Karolinska Sjukhuset, Stockholm

---

Article: I. Lidfeldt J, Nerbrand C, Samsioe, G, Scherstén B, Agardh C-D. A screening procedure detecting high-yield candidates for OGTT. The Women’s Health In the Lund Area (WHILA) Study: A population based study of middle-aged Swedish women. Eur J Epidemiol 2001; 17: 943-951.

Article: II. Lidfeldt J, Nyberg P, Nerbrand C, Samsioe G, Scherstén B, Agardh C-D. Socio-demographic and psychosocial factors are associated with features of the metabolic syndrome. The Women’s Health In the Lund Area (WHILA) Study. Diabetes Obes Metab 2003; 5: 106-112.

Article: III. Lidfeldt J, Nyberg P, Nerbrand C, Öjehagen A, Samsioe G, Scherstén B, Agardh C-D. Biolgical factors are more important than socio-demographic and psychosocial conditions in relation to hypertension in middle-aged women. The Women’s Health In the Lund Area (WHILA) Study. Blood Press 2002; 11: 270-278.

Article: IV. Lidfeldt J, Holmdahl L, Samsioe G, Nerbrand C, Nyberg P, Scherstén B, Agardh C-D. The influence of hormonal status and features of the metabolic syndrome on bone density: A population based study of Swedish women aged 50 to 59 years. The Women´s Health in the Lund Area (WHILA) Study. Metabolism 2002; 51: 267-270.

Article: V. Lidfeldt J, Nyberg P, Nerbrand C, Samsioe G, Scherstén B, Agardh C-D. Adherence to basic lifestyle advices reduces the risk for type 2 diabetes in high-risk middle-aged women, but is modified by socio-demographic factors. The Women’s Health in the Lund Area (WHILA) Study (Submitted).

Subject classification (UKÄ)

Health Sciences

Free keywords

epidemiology
Folkhälsa
epidemiologi
Public health
psychosocial.
socio-demographic
metabolic syndrome
Middle-aged women
diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Health in middle-aged women, with emphasis on features of the metabolic syndrome and related markers for diabetes. Women´s Health in the Lund Area Study.",

abstract = "The aims were to study the biological, socio-demographic and psychosocial health profile in a geographically defined population of middle-aged women, with focus on features of the metabolic syndrome and diabetes, and to study the efficiency of a screening method for high-risk individuals and the outcome of baseline lifestyle advices on the diabetes incidence. All women aged 50-59 years (n=10766) were invited to a screening procedure including questionnaires and laboratory assessments. Subjects were discriminated as positive or negative on one to eight variables linked to the metabolic syndrome. Those with positive screening and impaired glucose tolerance (IGT) at oral glucose tolerance test, were followed for 2.5 years after a one-hour session of lifestyle advices. A sub-sample of women with negative screening and normal glucose tolerance (NGT) were also studied at follow-up. Altogether, 6917 women attended the study and 93% were postmenopausal. Nearly half had hormone replacement therapy (HRT). A positive screening profile was found in 51%, and 14% had IGT and 6,4% diabetes, out of whom 4.8% were previously unknown. High blood glucose, waist hip ratio and body mass index were the most important factors associated with glucose intolerance. The screening instrument showed a sensitivity of 80% and a specificity of 55%. A total of 27% had hypertension. The prevalence of osteoporosis was 6.6%. In the longitudinal study, 11.9% of women with IGT developed diabetes, while 38% turned normal. In the group with NGT no one developed diabetes. Biological factors interrelated with socio-demographic and psychosocial disparities, like low level of education, living single and low subjective physical well-being. Low or moderate alcohol consumption seemed beneficial on the metabolic profile. The results on smoking and HRT were contradictory concerning the effect on features of the metabolic syndrome, while more crucial for the bone density. A high prevalence of risk variables was found, and many cases of IGT and diabetes. Screening of women at high risk for diabetes should be performed, and the biological risk profile considered jointly with socio-demographic and psychosocial factors. A one-hour baseline occasion of lifestyle advices reduces significantly the risk for new cases of diabetes.",

keywords = "epidemiology, Folkh{\"a}lsa, epidemiologi, Public health, psychosocial., socio-demographic, metabolic syndrome, Middle-aged women, diabetes",

author = "Jonas Lidfeldt",

note = "Defence details Date: 2003-04-11 Time: 10:15 Place: Jubileumsaulan, Ing{\aa}ng 59, UMAS External reviewer(s) Name: {\"O}stenson, Claes-G{\"o}ran Title: Prof. Affiliation: Karolinska Sjukhuset, Stockholm --- Article: I. Lidfeldt J, Nerbrand C, Samsioe, G, Scherst{\'e}n B, Agardh C-D. A screening procedure detecting high-yield candidates for OGTT. The Women{\textquoteright}s Health In the Lund Area (WHILA) Study: A population based study of middle-aged Swedish women. Eur J Epidemiol 2001; 17: 943-951. Article: II. Lidfeldt J, Nyberg P, Nerbrand C, Samsioe G, Scherst{\'e}n B, Agardh C-D. Socio-demographic and psychosocial factors are associated with features of the metabolic syndrome. The Women{\textquoteright}s Health In the Lund Area (WHILA) Study. Diabetes Obes Metab 2003; 5: 106-112. Article: III. Lidfeldt J, Nyberg P, Nerbrand C, {\"O}jehagen A, Samsioe G, Scherst{\'e}n B, Agardh C-D. Biolgical factors are more important than socio-demographic and psychosocial conditions in relation to hypertension in middle-aged women. The Women{\textquoteright}s Health In the Lund Area (WHILA) Study. Blood Press 2002; 11: 270-278. Article: IV. Lidfeldt J, Holmdahl L, Samsioe G, Nerbrand C, Nyberg P, Scherst{\'e}n B, Agardh C-D. The influence of hormonal status and features of the metabolic syndrome on bone density: A population based study of Swedish women aged 50 to 59 years. The Women´s Health in the Lund Area (WHILA) Study. Metabolism 2002; 51: 267-270. Article: V. Lidfeldt J, Nyberg P, Nerbrand C, Samsioe G, Scherst{\'e}n B, Agardh C-D. Adherence to basic lifestyle advices reduces the risk for type 2 diabetes in high-risk middle-aged women, but is modified by socio-demographic factors. The Women{\textquoteright}s Health in the Lund Area (WHILA) Study (Submitted).",

year = "2003",

language = "English",

isbn = "91-628-5562-X",

publisher = "Jonas Lidfeldt, FoUU Primary Health Care, University Hospital Lund, 221 85 Lund,",

school = "Department of Health Sciences",

}

TY - THES

T1 - Health in middle-aged women, with emphasis on features of the metabolic syndrome and related markers for diabetes. Women´s Health in the Lund Area Study.

AU - Lidfeldt, Jonas

N1 - Defence details Date: 2003-04-11 Time: 10:15 Place: Jubileumsaulan, Ingång 59, UMAS External reviewer(s) Name: Östenson, Claes-Göran Title: Prof. Affiliation: Karolinska Sjukhuset, Stockholm --- Article: I. Lidfeldt J, Nerbrand C, Samsioe, G, Scherstén B, Agardh C-D. A screening procedure detecting high-yield candidates for OGTT. The Women’s Health In the Lund Area (WHILA) Study: A population based study of middle-aged Swedish women. Eur J Epidemiol 2001; 17: 943-951. Article: II. Lidfeldt J, Nyberg P, Nerbrand C, Samsioe G, Scherstén B, Agardh C-D. Socio-demographic and psychosocial factors are associated with features of the metabolic syndrome. The Women’s Health In the Lund Area (WHILA) Study. Diabetes Obes Metab 2003; 5: 106-112. Article: III. Lidfeldt J, Nyberg P, Nerbrand C, Öjehagen A, Samsioe G, Scherstén B, Agardh C-D. Biolgical factors are more important than socio-demographic and psychosocial conditions in relation to hypertension in middle-aged women. The Women’s Health In the Lund Area (WHILA) Study. Blood Press 2002; 11: 270-278. Article: IV. Lidfeldt J, Holmdahl L, Samsioe G, Nerbrand C, Nyberg P, Scherstén B, Agardh C-D. The influence of hormonal status and features of the metabolic syndrome on bone density: A population based study of Swedish women aged 50 to 59 years. The Women´s Health in the Lund Area (WHILA) Study. Metabolism 2002; 51: 267-270. Article: V. Lidfeldt J, Nyberg P, Nerbrand C, Samsioe G, Scherstén B, Agardh C-D. Adherence to basic lifestyle advices reduces the risk for type 2 diabetes in high-risk middle-aged women, but is modified by socio-demographic factors. The Women’s Health in the Lund Area (WHILA) Study (Submitted).

PY - 2003

Y1 - 2003

N2 - The aims were to study the biological, socio-demographic and psychosocial health profile in a geographically defined population of middle-aged women, with focus on features of the metabolic syndrome and diabetes, and to study the efficiency of a screening method for high-risk individuals and the outcome of baseline lifestyle advices on the diabetes incidence. All women aged 50-59 years (n=10766) were invited to a screening procedure including questionnaires and laboratory assessments. Subjects were discriminated as positive or negative on one to eight variables linked to the metabolic syndrome. Those with positive screening and impaired glucose tolerance (IGT) at oral glucose tolerance test, were followed for 2.5 years after a one-hour session of lifestyle advices. A sub-sample of women with negative screening and normal glucose tolerance (NGT) were also studied at follow-up. Altogether, 6917 women attended the study and 93% were postmenopausal. Nearly half had hormone replacement therapy (HRT). A positive screening profile was found in 51%, and 14% had IGT and 6,4% diabetes, out of whom 4.8% were previously unknown. High blood glucose, waist hip ratio and body mass index were the most important factors associated with glucose intolerance. The screening instrument showed a sensitivity of 80% and a specificity of 55%. A total of 27% had hypertension. The prevalence of osteoporosis was 6.6%. In the longitudinal study, 11.9% of women with IGT developed diabetes, while 38% turned normal. In the group with NGT no one developed diabetes. Biological factors interrelated with socio-demographic and psychosocial disparities, like low level of education, living single and low subjective physical well-being. Low or moderate alcohol consumption seemed beneficial on the metabolic profile. The results on smoking and HRT were contradictory concerning the effect on features of the metabolic syndrome, while more crucial for the bone density. A high prevalence of risk variables was found, and many cases of IGT and diabetes. Screening of women at high risk for diabetes should be performed, and the biological risk profile considered jointly with socio-demographic and psychosocial factors. A one-hour baseline occasion of lifestyle advices reduces significantly the risk for new cases of diabetes.

AB - The aims were to study the biological, socio-demographic and psychosocial health profile in a geographically defined population of middle-aged women, with focus on features of the metabolic syndrome and diabetes, and to study the efficiency of a screening method for high-risk individuals and the outcome of baseline lifestyle advices on the diabetes incidence. All women aged 50-59 years (n=10766) were invited to a screening procedure including questionnaires and laboratory assessments. Subjects were discriminated as positive or negative on one to eight variables linked to the metabolic syndrome. Those with positive screening and impaired glucose tolerance (IGT) at oral glucose tolerance test, were followed for 2.5 years after a one-hour session of lifestyle advices. A sub-sample of women with negative screening and normal glucose tolerance (NGT) were also studied at follow-up. Altogether, 6917 women attended the study and 93% were postmenopausal. Nearly half had hormone replacement therapy (HRT). A positive screening profile was found in 51%, and 14% had IGT and 6,4% diabetes, out of whom 4.8% were previously unknown. High blood glucose, waist hip ratio and body mass index were the most important factors associated with glucose intolerance. The screening instrument showed a sensitivity of 80% and a specificity of 55%. A total of 27% had hypertension. The prevalence of osteoporosis was 6.6%. In the longitudinal study, 11.9% of women with IGT developed diabetes, while 38% turned normal. In the group with NGT no one developed diabetes. Biological factors interrelated with socio-demographic and psychosocial disparities, like low level of education, living single and low subjective physical well-being. Low or moderate alcohol consumption seemed beneficial on the metabolic profile. The results on smoking and HRT were contradictory concerning the effect on features of the metabolic syndrome, while more crucial for the bone density. A high prevalence of risk variables was found, and many cases of IGT and diabetes. Screening of women at high risk for diabetes should be performed, and the biological risk profile considered jointly with socio-demographic and psychosocial factors. A one-hour baseline occasion of lifestyle advices reduces significantly the risk for new cases of diabetes.

KW - epidemiology

KW - Folkhälsa

KW - epidemiologi

KW - Public health

KW - psychosocial.

KW - socio-demographic

KW - metabolic syndrome

KW - Middle-aged women

KW - diabetes

M3 - Doctoral Thesis (compilation)

SN - 91-628-5562-X

PB - Jonas Lidfeldt, FoUU Primary Health Care, University Hospital Lund, 221 85 Lund,

ER -

Health in middle-aged women, with emphasis on features of the metabolic syndrome and related markers for diabetes. Women´s Health in the Lund Area Study.

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

UN SDGs

Fingerprint

Cite this