@phdthesis{03a185ead5e84886b40a4baadf6162ee,
title = "Healthy Satiety Effects of Paleolithic diet on Satiety and Risk factors for Cardiovascular disease",
abstract = "The prevalence of cardiovascular diseases (CVD) exhibits considerable variation across agrarian societies, whereas they are virtually absent in non-agrarian societies such as hunter-gatherer and horticultural societies. When looking for lifestyle factors which could promote CVD, it therefore seems logical to focus on the agrarian lifestyle and ways in which it departs from a non-agrarian lifestyle. The aim of this thesis was to evaluate the effect of a hunter-gatherer diet (also called Paleolithic diet) compared to agrarian diet in prevention of CVD. In paper I we reviewed evidence from epidemiology and evolutionary biology for a possible maladaptation of human satiety hormone leptin to agrarian diet. We found that leptin resistance hypothetically may be a sign of maladaptation to dietary cereals as staple food, and that lectins could be a cereal constituent with sufficient properties to cause leptin resistance. In paper II we experimentally studied the long-term effect of a Paleolithic diet compared to a cereal-based diet on risk factors for cardiovascular disease in domestic pigs. We found that a Paleolithic diet conferred higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet. In paper III and IV we experimentally studied the effect of a Paleolithic diet compared to a Mediterranean-like diet on risk factors for cardiovascular disease, satiety and leptin in individuals with ischaemic heart disease and either glucose intolerance or type 2 diabetes. Paper III showed that a Paleolithic diet improved glucose tolerance more than a Mediterranean-like diet, and paper IV showed that a Paleolithic diet was more satiating per calorie than a Mediterranean-like diet. In conclusion, we have found beneficial effects of a Paleolithic diet on risk factors for cardiovascular disease and satiety.",
keywords = "Cardiovascular system, diabetologi, sekretion, Endokrinologi, Cardiovascular Disease, Paleolithic Diet, Satiety, Endocrinology, diabetology, secreting systems, Kardiovaskul{\"a}ra systemet",
author = "Tommy J{\"o}nsson",
note = "Defence details Date: 2007-11-23 Time: 13:00 Place: F{\"o}rel{\"a}sningssal 3, Lund University Hospital, Lund, Sweden External reviewer(s) Name: Hell{\'e}nius, Mai-Lis Title: Professor Affiliation: Karolinska Institutet, Institutionen f{\"o}r neurobiologi, v{\aa}rdvetenskap och samh{\"a}lle, Sektionen f{\"o}r all --- <div class={"}article_info{"}>T J{\"o}nsson, S Olsson, B Ahr{\'e}n, TC B{\o}g-Hansen, A Dole and S Lindeberg. <span class={"}article_issue_date{"}>2005</span>. <span class={"}article_title{"}>Agrarian diet and diseases of affluence - Do evolutionary novel dietary lectins cause leptin resistance?</span> <span class={"}journal_series_title{"}>BMC Endocr Disord</span>, <span class={"}journal_volume{"}>vol 5</span> </div> <div class={"}article_info{"}>T J{\"o}nsson, B Ahr{\'e}n, G Pacini, F Sundler, N Wierup, S Steen, T Sj{\"o}berg, M Ugander, J Frosteg{\aa}rd, L G{\"o}ransson and S Lindeberg. <span class={"}article_issue_date{"}>2006</span>. <span class={"}article_title{"}>A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs.</span> <span class={"}journal_series_title{"}>Nutr Metab (Lond)</span>, <span class={"}journal_volume{"}>vol 3</span> </div> <div class={"}article_info{"}>S Lindeberg, T J{\"o}nsson, Y Granfeldt, E Borgstrand, J Soffman, K Sj{\"o}str{\"o}m and B Ahr{\'e}n. <span class={"}article_issue_date{"}>2007</span>. <span class={"}article_title{"}>A Paleolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischemic heart disease.</span> <span class={"}journal_series_title{"}>Diabetologia</span>, <span class={"}journal_volume{"}>vol 50</span> <span class={"}journal_pages{"}>pp 1795-807</span>.</div> <div class={"}article_info{"}>T J{\"o}nsson, Y Granfeldt, C Erlanson-Albertsson, B Ahr{\'e}n and S Lindeberg. <span class={"}article_issue_date{"}></span>. <span class={"}article_title{"}>A Paleolithic diet is more satiating per calorie than a Mediterranean-like diet in individuals with ischemic heart disease.</span> (submitted)</div>",
year = "2007",
language = "English",
isbn = "978-91-85897-23-0",
series = "Faculty of Medicine Doctoral Dissertation Series ",
publisher = "Division of Family Medicine Department of Clinical Sciences Lund University Sweden",
type = "Doctoral Thesis (compilation)",
school = "Medicine/Emergency Medicine, Lund",
}